지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 114 - 122 (9page)
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초록· 키워드
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Objective : Silent corticotroph adenomas (SCA) are endocrine-inactive pituitary adenomas with positive immunohistochemistry staining for adrenocorticotropic hormone (ACTH). We investigated whether SCA-associated clinical profiles were more aggressive than hormonally negative adenomas (HNA). Methods : Among 627 patients with pathologically proven endocrine-inactive pituitary adenomas between 2004 and 2013, positive immunohistochemistry revealed 55 SCAs and 411 HNAs. Surgical outcomes and radiological and endocrinological characteristics were compared. Results : Strong female predominance was observed in the SCA group (p<0.001). Cavernous sinus invasion was identified in 22 (40%) SCA patients and 72 (17.6%) HNA patients (p<0.001). There were no differences in ACTH or cortisol levels between the two groups. The incidence of preoperative hypopituitarism and postoperative hormonal outcome did not differ between two groups. Total resection was achieved in 35 patients (63.7%) with SCA and 332 patients (80.8%) with HNA (p=0.007). When tumors were completely removed, recurrence rates were not statistically different between two groups (p=0.60). When complete resection was not achieved, tumors regrew from these remnants in seven patients (35.0%) with SCA and 12 patients (15.2%) with HNA (p=0.05). Conclusion : Total surgical resection for SCA is often challenging as these tumors frequently invade a cavernous sinus. Early remnant tumor intervention is justified, because untreated residual pituitary tumors regrow when patients were followed up for a long time. Prophylactic radiotherapy is not warranted for completely resected SCAs as tumor recurrence is uncommon.
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참고문헌 (15)
참고문헌 신청
Alahmadi H / 2012 / Clinical features of silent corticotroph adenomas / Acta Neurochir (Wien) 154:1493~1498
Baldeweg SE / 2005 / A spectrum of behaviour in silent corticotroph pituitary adenomas / Br J Neurosurg 19:38~42
Bradley KJ / 2003 / Non-functioning pituitary adenomas with positive immunoreactivity for ACTH behave more aggressively than ACTH immunonegative tumours but do not recur more frequently / Clin Endocrinol (Oxf) 58:59~64
Cho HY / 2010 / Silent corticotroph adenomas have unique recurrence characteristics compared with other nonfunctioning pituitary adenomas / Clin Endocrinol (Oxf) 72:648~653
Horvath E / 1980 / Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study / Am J Pathol 98:617~638
Baldeweg SE / 2005 / A spectrum of behaviour in silent corticotroph pituitary adenomas / Br J Neurosurg 19:38~42
Bradley KJ / 2003 / Non-functioning pituitary adenomas with positive immunoreactivity for ACTH behave more aggressively than ACTH immunonegative tumours but do not recur more frequently / Clin Endocrinol (Oxf) 58:59~64
Cho HY / 2010 / Silent corticotroph adenomas have unique recurrence characteristics compared with other nonfunctioning pituitary adenomas / Clin Endocrinol (Oxf) 72:648~653
Horvath E / 1980 / Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study / Am J Pathol 98:617~638
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