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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제61권 제4호
- 발행연도
- 2018.1
- 수록면
- 411 - 416 (6page)
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초록· 키워드
오류제보하기
Chlorpyrifos (CPF) is one of the most heavily used organophosphate pesticides and is useful as an insecticide drug. However, CPF also causes toxic effects in nontarget organisms, including humans and animals. Jageum-Jung (JGJ) is a traditional oriental medicine, composed of five specific herbs with antioxidant and hepatoprotective properties, used for detoxification. In the present study, highly concentrated CPF was orally administrated to male Institute of Cancer Research mice to produce acute toxicity, and the protective effects of JGJ administration were investigated through statistical analysis of changes in body and organ weights and serum biochemical parameters. JGJ caused body and organ weights to recover and reduced the levels of serum biochemical parameters indicative of liver damage, such as glutamic oxalate transaminase, glutamic pyruvate transaminase, alkaline phosphatase, lactic dehydrogenase, urea, glucose, total cholesterol, and triglyceride, that had been increased by CPF treatment. Our results demonstrated that JGJ ameliorates the effects of acute chlorpyrifos-induced toxicity. Therefore, JGJ has the potential to be used as a traditional medicine to alleviate insecticide toxicity.
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참고문헌 (39)
참고문헌 신청
Cetin N / 2007 / Chlorpyrifos induces cardiac dysfunction in rabbits / Res Vet Sci 82(3):405~408
Saulsbury MD / 2009 / Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells / Toxicology 259(1-2):1~9
Sandahl JF / 2005 / Comparative thresholds for acetylcholinesterase inhibition and behavioral impairment in coho salmon exposed to chlorpyrifos / Environ Toxicol Chem 24(1):136~145
Khan SM / 2007 / Subacute oral toxicity of chlorpyriphos and protective effect of green tea extract / Pestic Biochem Phys 89(2):118~123
Verma RS / 2007 / In vivo chlorpyrifos induced oxidative stress: Attenuation by antioxidant vitamins / Pestic Biochem Phys 88(2):191~196
Saulsbury MD / 2009 / Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells / Toxicology 259(1-2):1~9
Sandahl JF / 2005 / Comparative thresholds for acetylcholinesterase inhibition and behavioral impairment in coho salmon exposed to chlorpyrifos / Environ Toxicol Chem 24(1):136~145
Khan SM / 2007 / Subacute oral toxicity of chlorpyriphos and protective effect of green tea extract / Pestic Biochem Phys 89(2):118~123
Verma RS / 2007 / In vivo chlorpyrifos induced oxidative stress: Attenuation by antioxidant vitamins / Pestic Biochem Phys 88(2):191~196
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