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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.26 No.3
- 발행연도
- 2021.9
- 수록면
- 315 - 320 (6page)
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초록· 키워드
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Acute and subacute toxicity tests were undertaken on a novel galacto-oligosaccharide (GOS) produced from lactose by β-galactosidase derived from Bacillus circulans. Toxicity was evaluated by single dose oral administration (5,000 mg/kg) and was repeated at day 28 (1,000 mg/kg) in male and female Sprague-Dawley rats. In acute toxicity tests, the protein levels of male rats administered GOS showed a significant difference from controls, but remained within the normal range. There were no GOS-related changes in clinical symptoms, weight, food intake, hematology, blood chemistry, relative organ weight, or severe pathology in rats treated with GOS compared with controls. The no observed adverse effect level of GOS was at least 1,000 mg/kg/d in both male and female rats. Bovine-specific genes were not detected in GOS 70%-based products (NeoGOS-P70, NeoGOS-L70, and organic GOS), indirectly showing the absence of an allergen and that products containing GOS 70% are non-toxic and allergen-free.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Albayrak N / 2002 / Production of galacto-oligosaccharides from lactose by Aspergillus oryzae β-galactosidase immobilized on cotton cloth / Biotechnol Bioeng 77:8~19
Andersson H / 2001 / Health effects of probiotics and prebiotics－a literature review on human studies / Food Nutr Res 45:58~75
Anthony JC / 2006 / 90-Day oral(gavage)study in rats with galactooligosaccharides syrup / Food Chem Toxicol 44:819~826
Bode L. / 2020 / Human milk oligosaccharides: structure and functions / Nestle Nutr Inst Workshop Ser 94:115~123
Boon MA / 2000 / Effect of temperature and enzyme origin on the enzymatic synthesis of oligosaccharides / Enzyme Microb Technol 26:271~281
Andersson H / 2001 / Health effects of probiotics and prebiotics－a literature review on human studies / Food Nutr Res 45:58~75
Anthony JC / 2006 / 90-Day oral(gavage)study in rats with galactooligosaccharides syrup / Food Chem Toxicol 44:819~826
Bode L. / 2020 / Human milk oligosaccharides: structure and functions / Nestle Nutr Inst Workshop Ser 94:115~123
Boon MA / 2000 / Effect of temperature and enzyme origin on the enzymatic synthesis of oligosaccharides / Enzyme Microb Technol 26:271~281
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