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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 157 - 169 (13page)
- DOI
- 10.7783/KJMCS.2018.26.2.157
이용수
초록· 키워드
오류제보하기
Background: Cassia tora L., an annual or perennial plant of the Fabaceae family, is traditional medicine with various biological activities, including anti-constipation and, anti-inflammation. Chemical compounds such as anthraquinone glycoside and naphthalene derivatives have been isolated from this plant. Cassia tora L. is a common contaminant of agricultural commodities, but is toxic to cattle and poultry.
Methods and Results: To investigate the potential toxicity, Cassia tora L. aqueous extract (CO) was administered orally to rats for 26 weeks at 0 (control), 300, 1,500 and 3,000㎎/㎏/day (n = 10 for male rats for each dose). The positive control comprised animals orally administered anthraquinone 100㎎/㎏/day. There was no treatment-related mortality. An increase in the kidney weight was observed at 3,000㎎/㎏/day of CO and anthraquinone 100㎎/㎏/day. Macrophage infiltration in the colon was observed at CO 1,500 and 3,000㎎/㎏/day and anthraquinone 100㎎/㎏/day, but there were no significant toxicological changes in the incidence and severity of the finding.
Conclusions: The oral no-observed-adverse-effect level (NOAEL) of CO was 3,000㎎/㎏/day in male rats and no target organs were identified. In addition, 300㎎/㎏ was found to be the no-observed-effect level (NOEL) for systemic toxicity under the conditions of the study.
Methods and Results: To investigate the potential toxicity, Cassia tora L. aqueous extract (CO) was administered orally to rats for 26 weeks at 0 (control), 300, 1,500 and 3,000㎎/㎏/day (n = 10 for male rats for each dose). The positive control comprised animals orally administered anthraquinone 100㎎/㎏/day. There was no treatment-related mortality. An increase in the kidney weight was observed at 3,000㎎/㎏/day of CO and anthraquinone 100㎎/㎏/day. Macrophage infiltration in the colon was observed at CO 1,500 and 3,000㎎/㎏/day and anthraquinone 100㎎/㎏/day, but there were no significant toxicological changes in the incidence and severity of the finding.
Conclusions: The oral no-observed-adverse-effect level (NOAEL) of CO was 3,000㎎/㎏/day in male rats and no target organs were identified. In addition, 300㎎/㎏ was found to be the no-observed-effect level (NOEL) for systemic toxicity under the conditions of the study.
목차
ABSTRACT
서언
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (33)
참고문헌 신청
Ayodele AAE / 2015 / Acute toxicity and some elemental assessment of Senna tora Linn thylakoids in natural population of northeastern nigeria / International Journal of Research 2:375~381
Choi JS / 1996 / The NMR assignments of anthraquinones from Cassia tora / Archives of Pharmacal Research 19:302~306
Choi JS / 1994 / Alatemin, cassiaside and rubrofusarin gentiobioside, radical scavenging principles from the seeds of Cassia tora on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical / Archives of Pharmacal Research 17:462~466
Choi JS / 1997 / In vitro antimutagenic effects of anthraquinone aglycones and naphthopyrone glycosides from Cassia tora / Planta Medica 63:11~14
Cholendra A / 2014 / Acute toxicity studies of Cassia tora leaf powder / International Journal of Immunopathology and Pharmacology 4:176~181
Choi JS / 1996 / The NMR assignments of anthraquinones from Cassia tora / Archives of Pharmacal Research 19:302~306
Choi JS / 1994 / Alatemin, cassiaside and rubrofusarin gentiobioside, radical scavenging principles from the seeds of Cassia tora on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical / Archives of Pharmacal Research 17:462~466
Choi JS / 1997 / In vitro antimutagenic effects of anthraquinone aglycones and naphthopyrone glycosides from Cassia tora / Planta Medica 63:11~14
Cholendra A / 2014 / Acute toxicity studies of Cassia tora leaf powder / International Journal of Immunopathology and Pharmacology 4:176~181
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