CHANGING OF RGS TRANSCRIPTS LEVELS BY LOW-DOSE-RATE IONIZING RADIATION IN MOUSE TESTIS

Kim, Tae-Hwan; Baik, Ji Sue; Heo, Kyu; Kim, Joong Sun; Lee, Ki Ja; Rhee, Man Hee; Kim, Sung Dae

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자료유형: 학술저널

저자정보: Kim, Tae-Hwan (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University) Baik, Ji Sue (Research Center, Dongnam Institute of Radiological & Medical Sciences) Heo, Kyu (Research Center, Dongnam Institute of Radiological & Medical Sciences) Kim, Joong Sun (Research Center, Dongnam Institute of Radiological & Medical Sciences) Lee, Ki Ja (Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University) Rhee, Man Hee (Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University) Kim, Sung Dae (Research Center, Dongnam Institute of Radiological & Medical Sciences)

저널정보: 대한방사선방어학회 방사선방어학회지 방사선방어학회지 제40권 제3호

발행연도: 2015.1

수록면: 187 - 193 (7page)

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Deleterious effects of high dose radiation exposure with high-dose-rate are unarguable, but they are still controversial in low-dose-rate. The regulator of G-protein signaling (RGS) is a negative regulator of G protein-coupled receptor (GPCR) signaling. In addition, it is reported that irradiation stress led to GPCR-mediated mitogen-activated protein kinase (MAPK) and phosphotidylinositol 3-kinase (PI3-k) signaling. The RGS mRNA expression profiles by whole body radiation with low-dose-rate has not yet been explored. In the present study, we, therefore, examined which RGS was modulated by the whole body radiation with low-dose-rate ($3.49mGy{\cdot}h^{-1}$). Among 16 RGS expression tested, RGS6, RGS13 and RGS16 mRNA were down-regulated by low-dose-rate irradiation. This is the first report that whole body radiation with low-dose-rate can modulate the different RGS expression levels. These results are expected to reveal the potential target and/or the biomarker proteins associated with male testis toxicity induced by low-dose-rate irradiation, which might contribute to understanding the mechanism beyond the testis toxicity.

#Gamma radiation #Low-dose-rate #RGS #Testis

참고문헌 (33)

참고문헌 신청

Endale M / 2010 / Ischemia induces regulator of G protein signaling 2(RGS2) protein upregulation and enhances apoptosis in astrocytes / Am J Physiol Cell Physiol 298:C611~C623

Iwaki S / 2011 / p53 negatively regulates RGS13 protein expression in immune cells 286(25):22219~22226

Hepler JR / 2003 / RGS protein and G protein interactions : a little help from their friends / Mol Pharmacol 64(3):547~549

Druey KM / 2001 / Bridging with GAPs: receptor communication through RGS proteins / Sci STKE 2001(104):re14

Hendriks-Balk MC / 2008 / Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins / Eur J Pharmacol 585(2-3):278~291

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Kim, Tae-Hwan

소속기관 Laboratory of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University