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논문 기본 정보

자료유형
학술저널
저자정보
Ahmad, Bashir (Laboratory of Endocrinology, Department of Bioscience, Barkatullah University) Shrivastava, Vinoy K. (Laboratory of Endocrinology, Department of Bioscience, Barkatullah University) Saleh, Ramadan (Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University) Henkel, Ralf (Department of Medical Bioscience, University of the Western Cape) Agarwal, Ashok (American Center for Reproductive Medicine, Urological Institute, Cleveland Clinic)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제45권 제4호
발행연도
2018.1
수록면
163 - 169 (7page)

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Objective: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. Methods: Ninety 8-week-old female mice were randomly allocated into three treatment groups. The first group received an intraperitoneal injection of ZEA (2.5 mg/kg) on alternate days. The second group received ZEA (2.5 mg/kg) on alternate days plus oral saffron daily (50 mg/kg). The third group was treated with a vehicle of 1% dimethyl sulfoxide (DMSO) on alternate days, as a control. Ten mice were euthanized from each group at 30, 60, and 90 days of treatment. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol ($E_2$), and progesterone (P) were assessed. The uterus and ovaries were examined for changes in size or morphology. Results: Serum levels of LH, FSH, $E_2$, and P in the female mice treated with ZEA plus saffron were significantly higher than in those treated with ZEA alone, and were not significantly different from those treated with 1% DMSO. The female mice treated with ZEA alone showed a reduction in size of the uterus and abnormal architecture of the ovaries. Conclusion: The administration of saffron to female mice resulted in a significant reduction in ZEA-induced alterations in reproductive hormone levels, the size of the uterus, and the morphology of the ovaries.

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