Single Nucleotide Polymorphisms in STAT3 and STAT4 and Risk of Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B

Chanthra, Nawin; Payungporn, Sunchai; Chuaypen, Natthaya; Piratanantatavorn, Kesmanee; Pinjaroen, Nutcha; Poovorawan, Yong; Tangkijvanich, Pisit

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자료유형: 학술저널

저자정보: Chanthra, Nawin (Research Unit of Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University) Payungporn, Sunchai (Research Unit of Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University) Chuaypen, Natthaya (Research Unit of Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University) Piratanantatavorn, Kesmanee (Department of Biochemistry, Faculty of Medicine, Chulalongkorn University) Pinjaroen, Nutcha (Department of Radiology, Faculty of Medicine, Chulalongkorn University) Poovorawan, Yong (Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University) Tangkijvanich, Pisit (Research Unit of Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제18호

발행연도: 2015.1

수록면: 8,405 - 8,410 (6page)

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Hepatitis B virus (HBV) infection is the leading cause of hepatocellular carcinoma (HCC) development. Recent studies demonstrated that single nucleotide polymorphisms (SNPs) rs2293152 in signal transducer and activator of transcription 3 (STAT3) and rs7574865 in signal transducer and activator of transcription 4 (STAT4) are associated with chronic hepatitis B (CHB)-related HCC in the Chinese population. We hypothesized that these polymorphisms might be related to HCC susceptibility in Thai population as well. Study subjects were divided into 3 groups consisting of CHB-related HCC (n=192), CHB without HCC (n=200) and healthy controls (n=190). The studied SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results showed that the distribution of different genotypes for both polymorphisms were in Hardy-Weinberg equilibrium (P>0.05). Our data demonstrated positive association of rs7574865 with HCC risk when compared to healthy controls under an additive model (GG versus TT: odds ratio (OR)=2.07, 95% confidence interval (CI)=1.06-4.03, P=0.033). This correlation remained significant under allelic and recessive models (OR=1.46, 95% CI=1.09-1.96, P=0.012 and OR=1.71, 95% CI=1.13-2.59, P=0.011, respectively). However, no significant association between rs2293152 and HCC development was observed. These data suggest that SNP rs7574865 in STAT4 might contribute to progression to HCC in the Thai population.

#Chronic hepatitis B #hepatocellular carcinoma #STAT3 #STAT4 #single nucleotide polymorphisms

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Chanthra, Nawin

소속기관 Research Unit of Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulal