Association between Pax8-PPARγ1 Rearrangement and Follicular Thyroid Cancer: a Meta-Analysis

Li, Hang-Yu; Xie, Zhi-Hao; Xu, Cong-Hui; Pu, Mei-Ling; Chen, Zi-Yan; Yu, Miao; Wang, Heng-Shu; Zhou, Chen-Ming; Pu, Chao-Yu; Liu, Wei

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자료유형: 학술저널

저자정보: Li, Hang-Yu (Undergraduate of School of Public Health, Hebei Medical University) Xie, Zhi-Hao (Undergraduate of School of Public Health, Hebei Medical University) Xu, Cong-Hui (Undergraduate of School of Public Health, Hebei Medical University) Pu, Mei-Ling (Undergraduate of School of Public Health, Hebei Medical University) Chen, Zi-Yan (Undergraduate of School of Basic Medicine College, Hebei Medical University) Yu, Miao (Undergraduate of School of Basic Medicine College, Hebei Medical University) Wang, Heng-Shu (Department of Pathology, The Second Hospital of Hebei Medical University) Zhou, Chen-Ming (Department of Electronic Microscopy Center, Key Laboratory of Immune Mechanism and Intervention on Serious Disease, Basic Medical College, Hebei Medical University) Pu, Chao-Yu (Department of Nuclear Medicine, The General Hospital of Chinese People's Armed Police Force) Liu, Wei (Department of Immunology, Key Laboratory of Immune Mechanism and Intervention on Serious Disease, Basic Medical College, Hebei Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제9호

발행연도: 2016.1

수록면: 4,247 - 4,250 (4page)

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Background: Pax8 and peroxisome proliferator-activated receptor gamma 1 gene (Pax8-$PPAR{\gamma}1$) are important factors in tumors. Several studies have suggested that follicular thyroid cancer may arise from Pax8- $PPAR{\gamma}1$ rearrangement. In order to have a better understanding of the association between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer, we conducted the presenmt meta-analysis. Materials and Methods: The information was extracted from PubMed, EMBASE and Web of Science. Statistic analysis was performed with Stata12.0 software. Odds ratios (ORs) were calculated using a fixed-effects model. We also performed heterogeneity and publication bias analyses. Results: Nine studies including 198 follicular thyroid cancer patients and 268 controls were considered eligible. The frequency of Pax8-$PPAR{\gamma}1$ rearrangement was significantly higher in the follicular thyroid cancer group than in the control group, with a pooled OR of 6.63 (95%CI=3.50-12.7). In addition, through subgroup analysis, the OR between Pax8-$PPAR{\gamma}1$ rearrangement and follicular thyroid cancer was 6.04 (95%CI = 3.18-11.5) when using benign tumor tissues as controls. The OR for the method subgroup was 9.99 (95% CI =4.86-20.5) in the RT-PCR. Conclusions: The final results demonstrated that Pax8-$PPAR{\gamma}1$ rearrangement has significant association with follicular thyroid cancer.

#Follicular thyroid cancer #Pax8- $PPAR{gamma}1$ rearrangement #meta-analysis

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