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논문 기본 정보

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학술저널
저자정보
Murakami, Shinki (SAIDO Corporation) Eikawa, Shingo (Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) Kaya, Savas (Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences) Imao, Mitsuko (SAIDO Corporation) Aji, Toshiki (Department of Immunology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호
발행연도
2016.1
수록면
3,077 - 3,084 (8page)

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Various beneficial effects have been described for fermented papaya preparation (FPP: SAIDO-PS501) based on its anti-oxidative and anti-inflammatory functions. The present study was designed to determine the effects of FPP on carcinogenesis in vivo, and immunomodulatory function in vitro. Mice were injected with RL male 1 cells subcutaneously or 3-methylcholantherene (MCA) intravenously to induce cancer and orally or intraperitoneally treated with FPP solution. Human peripheral blood mononuclear cells (PBMC) were obtained from healthy volunteers and patients with atopic dermatitis, treated with FPP, and subjected to measurement of cytokine production and changes in Foxp3-expressing regulatory T cell (Treg) stimulated with phytohemagglutinin (PHA). Administration of FPP suppressed tumor size and the incidence of malignancy. In vitro, treatment of PBMC with FPP induced IL-$1{\beta}$, $TNF{\alpha}$ and $IFN{\gamma}$ production. Moreover, FPP suppressed proliferation of PHA-stimulated Foxp3-expressing Treg. These results suggest that FPP has chemotherapeutic properties.

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