Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction

Fabre, Bibiana; Grosman, Halina; Gonzalez, Diego; Machulsky, Nahuel Fernandez; Repetto, Esteban M; Mesch, Viviana; Lopez, Miguel Angel; Mazza, Osvaldo; Berg, Gabriela

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저자정보: Fabre, Bibiana (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires) Grosman, Halina (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires) Gonzalez, Diego (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires) Machulsky, Nahuel Fernandez (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires) Repetto, Esteban M (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires) Mesch, Viviana (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires) Lopez, Miguel Angel (Urology Division, Hospital de Clinicas. Universidad de Buenos Aires) Mazza, Osvaldo (Urology Division, Hospital de Clinicas. Universidad de Buenos Aires) Berg, Gabriela (Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호

발행연도: 2016.1

수록면: 3,167 - 3,171 (5page)

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Prostate cancer (PCa) is one of the most common diseases in men. It is important to assess prognostic factors and whether high cortisol levels and complex hormonal interactions could be responsible for PCa development. We evaluated the relationship between cortisol, leptin and estrogens in 141 men, 71 with PCa and the remaining 70 constituting a low risk group (LRG). They were recruited for this study from a total of 2906 middle-aged men (ages 45-70 years) who completed an evaluation for prostatic diseases at the Urology Division, Hospital de Clinicas "$Jos{\acute{e}}$ de San $Mart{\acute{i}}n$", University of Buenos Aires, in May 2009. In this cross sectional study, cortisol, PSA, total-testosterone, free-testosterone, bioavailable testosterone, LH and estradiol were measured in serum. We observed increased cortisol levels in PCa patients as compared to LRG cases (p=0.004,). Leptin and estradiol levels were also higher in PCa patients (p=0.048; p<0.0001, respectively). Logistic regression analysis indicated that serum cortisol (OR: 1.110 (95% CI 1.016-1.213), p=0.022), estradiol (OR: 1.044 (95% CI 1.008-1.081), p=0.016) and leptin (OR: 1.248 (95% CI 1.048-1.487), p=0.013) explained 27% of the variance of dependent variables, even after adjusting for age, smoking, BMI and waist circumference. We found increased cortisol levels in PCa patients as compared to LRG, as well as an altered circulating hormonal profile.

#Cortisol - leptin #prostate cancer #sex hormones

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Fabre, Bibiana

소속기관 Clinical Biochemistry Department, INFIBIOC, Facultad de Farmacia y Bioquimica, Universidad de Buenos