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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.8
- 수록면
- 599 - 607 (9page)
- DOI
- https://doi.org/10.3803/EnM.2022.1549
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초록· 키워드
오류제보하기
Accurate measurement of cortisol is critical in adrenal insufficiency as it reduces the risk associated with misdiagnosis and supportsthe optimization of stress dose. Comprehensive assays have been developed to determine the levels of bioactive free cortisol andtheir clinical and analytical efficacies have been extensively discussed because the level of total cortisol is affected by changes in thestructure or circulating levels of corticoid-binding globulin and albumin, which are the main reservoirs of cortisol in the human body.
Antibody-based immunoassays are routinely used in clinical laboratories; however, the lack of molecular specificity in cortisol assessment limits their applicability to characterize adrenocortical function. Improved specificity and sensitivity can be achieved bymass spectrometry coupled with chromatographic separation methods, which is a cutting-edge technology to measure individual aswell as a panel of steroids in a single analytical run. The purpose of this review is to introduce recent advances in free cortisol measurement from the perspectives of clinical specimens and issues associated with prospective analytical technologies.
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