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논문 기본 정보

자료유형
학술저널
저자정보
Kim, Jung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) Ryu, Ho-Ryong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) An, Joung-Jo (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) Namgung, Uk (Department of Neurophysiology, College of Oriental Medicine, Daejeon University) Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
저널정보
대한동의생리학회 동의생리병리학회지 동의생리병리학회지 제22권 제4호
발행연도
2008.1
수록면
896 - 902 (7page)

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Yukmijihwang-tang(YM) is used in Oriental medicine for treatments of diverse systemic symptoms including neurological dosorders. The present study was performed to examine potential effects of YM on growth-promoting activity of injured sciatic nerve axons. YM treatment in the injured sciatic nerve induced enhanced distal elongation of injured axons when measured 3 and 7 days after injury. Retrograde tracing of sciatic nerve axons showed YM-mediated increases in the number of DiI-labeled dorsal root ganglion (DRG) sensory neurons and spinal cord motor neurons at 3 days after injury. Hoechst nuclear staining showed that non-neuronal cell population was largely elevated by YM treatment in distal nerve area undergoing axonal regeneration. Furthermore, phospho-Erk1/2 protein levels were upregulated by YM treatment in the injured nerve area. These data suggest that YM may play a role in facilitated axonal regeneration in injured peripheral nerves. Further investigations of individual herbal components would be useful to explore effective molecular components and develop therapeutic strategies.

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