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논문 기본 정보

자료유형
학술저널
저자정보
Thakker, Shalin (Department of Pharmaceuticeutical technology, Postgraduate Studies and Research Center, SET's College of Phamacy) Biradar, S.M. (Department of Pharmacology, Postgraduate Studies and Research Center, SET's College of Phamacy) Habbu, P.V. (Department of Pharmacognosy, Postgraduate Studies and Research Center, SET's College of Phamacy) Mahadevan, K.M. (Department of Chemistry, School of Chemical Sciences, Kuvempu University) Thippeswamy, B.S. (Department of Pharmacology, Postgraduate Studies and Research Center, SET's College of Phamacy) Veerapur, V.P. (Department of Pharmaceutical Chemistry, Postgraduate Studies and Research Center, SET's College of Phamacy)
저널정보
경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제10권 제4호
발행연도
2010.1
수록면
278 - 287 (10page)

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The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.

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