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논문 기본 정보

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학술저널
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Choi, Eunhye (Department of Dental Anesthesiology, School of Dentistry, Seoul National University) Karm, Myong-Hwan (Department of Dental Anesthesiology, Seoul National University Dental Hospital) So, Eunsun (Department of Anesthesiology, School of Dentistry, Dankook University) Choi, Yoon Ji (Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital) Park, Sookyung (Department of Dental Anesthesiology, Seoul National University Dental Hospital) Oh, Yul (Department of Anesthesiology and Pain Medicine, Asan Medical Center) Yun, Hye Joo (Department of Dental Anesthesiology, Seoul National University Dental Hospital) Kim, Hyun Jeong (Department of Dental Anesthesiology, School of Dentistry, Seoul National University) Seo, Kwang-Suk (Department of Dental Anesthesiology, School of Dentistry, Seoul National University)
저널정보
대한치과마취과학회 Journal of dental anesthesia and pain medicine Journal of dental anesthesia and pain medicine 제19권 제1호
발행연도
2019.1
수록면
55 - 66 (12page)

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Background: Postoperative nausea and vomiting (PONV) frequently occurs following bimaxillary orthognathic surgeries. Compared to opioids, Nefopam is associated with lower incidences of PONV, and does not induce gastrointestinal tract injury, coagulopathy, nephrotoxicity, or fracture healing dysfunction, which are common side effects of Nonsteroidal anti-inflammatory drugs. We compared nefopam- and fentanyl-induced incidence of PONV in patients with access to patient-controlled analgesia (PCA) following bimaxillary orthognathic surgeries. Methods: Patients undergoing bimaxillary orthognathic surgeries were randomly divided into nefopam and fentanyl groups. Nefopam 120 mg or fentanyl $700{\mu}g$ was mixed with normal saline to a final volume of 120 mL. Patients were given access to nefopam or fentanyl via PCA. Postoperative pain intensity and PONV were measured at 30 minutes and 1 hour after surgery in the recovery room and at 8, 24, 48, and 72 hours after surgery in the ward. The frequency of bolus delivery was compared at each time point. Results: Eighty-nine patients were enrolled in this study, with 48 in the nefopam (N) group and 41 in the fentanyl (F) group. PONV occurred in 13 patients (27.7%) in the N group and 7 patients (17.1%) in the F group at 8 hours post-surgery (P = 0.568), and there were no significant differences between the two groups at any of the time points. VAS scores were $4.4{\pm}2.0$ and $3.7{\pm}1.9$ in the N and F groups, respectively, at 8 hours after surgery (P = 0.122), and cumulative bolus delivery was $10.7{\pm}13.7$ and $8.6{\pm}8.5$, respectively (P = 0.408). There were no significant differences in pain or bolus delivery at any of the remaining time points. Conclusion: Patients who underwent bimaxillary orthognathic surgery and were given nefopam via PCA did not experience a lower rate of PONV compared to those that received fentanyl via PCA. Furthermore, nefopam and fentanyl did not provide significantly different postoperative pain control.
#Fentanyl #Nefopam #Patient-Controlled Analgesia #Postoperative Nausea And Vomiting

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참고문헌 신청
Kim SY / 2015 / Nefopam as an adjunct to intravenous patient-controlled analgesia after renal transplantation : A randomised trial / Acta Anaesthesiol Scand 59:1068~1075 google schola 문지윤 / 2016 / The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study / The Korean Journal of Pain 29(2):110~118 dbpia Tirault M / 2006 / The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery / Anesth Analg 102:110~117 google schola

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