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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Jung Woo (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine) Han, Yea Sik (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine) Kim, Sin Rak (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine) Kim, Han Kyeol (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine) Kim, Hyun (Department of Anatomy, Kosin University College of Medicine) Park, Jin Hyung (Department of Plastic and Reconstructive Surgery, Kosin University College of Medicine)
저널정보
대한성형외과학회 Archives of plastic surgery : APS Archives of plastic surgery : APS 제42권 제2호
발행연도
2015.1
수록면
150 - 158 (9page)

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Background Fat is widely used in soft tissue augmentation. Nevertheless, it has an unpredictably high resorption rate. Clinically, external expansion with negative pressure is used to increase fat graft survival. In this study, fat graft recipient sites were preconditioned by external application of negative pressure in order to test for improvements in vascularity and fat graft survival. Methods Negative pressure was applied randomly to either the left or right dorsal ear of 20 New Zealand male white rabbits at a pressure of -125 mm Hg. The negative pressure was removed one week after the skin perfusion was measured. The skin flap at each ear was elevated, and 1 g of fat was grafted above the dorsal perichondrium. After one week, the fat weight, microvessel density, mature vessel density of the skin and fat, and amount of glycerol released were measured. Three months after the grafting, the same measurements were performed, with the exception of glycerol release. Results The fat survival rate of the experimental group ($75.4%{\pm}3.9%$) was higher than that of the control group ($53.1%{\pm}4.3%$) (P<0.001). Skin perfusion was higher in the experimental group. The glycerol release in the experimental group was significantly higher than in the control. The microvessel density of the skin and fat was significantly higher in the experimental group. Three months after the grafting, the skin and fat mature vessel density was significantly higher in the experimental groups. Conclusions Negative pressure prior to fat grafting increased the vascularity of the recipient site, and, accordingly, enhanced fat graft survival.
#Transplant donor site #Topical negative-pressure therapy #Adipose tissue #Autografts

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참고문헌 (22)

참고문헌 신청
Langer S / 2002 / Revascularization of transplanted adipose tissue: a study in the dorsal skinfold chamber of hamsters / Ann Plast Surg 48:53~59 google schola Del Vecchio DA / 2014 / The graft-to-capacity ratio: volumetric planning in large-volume fat transplantation / Plast Reconstr Surg 133:561~569 google schola Yazawa M / 2006 / Influence of vascularized transplant bed on fat grafting / Wound Repair Regen 14:586~592 google schola Schintler MV. / 2012 / Negative pressure therapy : theory and practice / Diabetes Metab Res Rev 28(Suppl 1):72~77 google schola Timmers MS / 2005 / The effects of varying degrees of pressure delivered by negative-pressure wound therapy on skin perfusion / Ann Plast Surg 55:665~671 google schola

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