두경부 편평 세포암의 원발 병소와 전이 경부 림프절에서 Matrix Metalloproteinase-9와 Basic Fibroblast Growth Factor의 발현

노영수; 황준식; 김진; 김진환; 조성진; 신형식

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자료유형: 학술저널

저자정보: 노영수 (한림대학교 의과대학 이비인후-두경부외과학교실) 황준식 (한림대학교 의과대학 이비인후-두경부외과학교실) 김진 (한림대학교 의과대학 이비인후-두경부외과학교실) 김진환 (한림대학교 의과대학 이비인후-두경부외과학교실) 조성진 (한림대학교 의과대학 병리학교실) 신형식 (한림대학교 의과대학 병리학교실)

저널정보: 대한두경부종양학회 대한 두경부 종양 학술지 대한 두경부 종양 학술지 제20권 제1호

발행연도: 2004.1

수록면: 13 - 18 (6page)

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Objectives: Cancer lethality is usually the result of local invasion and metastasis of neoplastic cell from the primary tumor. Because of their ability to degrade extracellular matrix components, matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) have been implicated in the breakdown of basement membrane and underlying stroma, thereby facilitating tumor growth and invasion. It has been well established that MMPs and bFGF expression correlate with cervical lymph node metastasis, but studies on expression in the metastatic cervical lymph node itself are not enough. We have analyzed matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) in squamous cell carcinoma of the head and neck and metastatic cervical lymph node, and evaluated their relationship and clinicophathologic significance. Material and Methods: 20 cases of squamous cell carcinoma of the head and neck were entered on the study of immunohistochemical stains for MMP-9 and bFGF in the obtained tissue from primary tumor and metastatic cervical lymph node. We analyzed the relationship between MMP-9, bFGF expression of the primary tumor and metastatic node with age, sex, T-stage, N-stage, histologic grade, pathologic stage and disease free survival. Results: Expression of MMP-9 and bFGF in cancer cell and metastatic lymph node was higher than that in normal cell and lymph node. According to histologic differentiation, expression of MMP-9 of the metastatic cervical lymph node was higher than primary tumor. Considering to other clinicopathologic factor, no statistical significance was seen in MMP-9 and bFGF. Conclusion: We found that expression of MMP-9 is higher in the metastatic lymph node than primary tumor in the poorly differentiated squamous cell carcinoma. But we don't find out the statistical significance in relation between bFGF and clinical factors. So we guess that some different mechanism of MMP-9 and bFGF in Head & Neck squamous cell carcinoma exist. Further studies will be necessary to establish their pathogenesis in the Head and Neck cancer.

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