지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Semisulospira libertine (SL) has been used as a folk medicine for quenching a thirst, hepatic fever and inflammation in oriental countries. Although SL has been anecdotally ascertained to ameliorate the hepatic diseases, there are no sufficient experimental evidences. The purpose of this study was to examine the effect of Bitam-S, in which SL is a main component, on non-alcoholic fatty liver disease manifested in C57BL/6J ob/ob mice. At 6 week old, the ob/ob mice were randomly divided into four groups; control and three treatment groups. The control mice was to receive a regular diet, and the treatment groups were fed a regular diet with either 250mg/kg, 500mg/kg of Bitam-S (BS250 and BS500) or 300mg/kg of metformin (MT300) for a 8-week period. Bitam-S exerted beneficial effects on lipid homeostasis in ob/ob mice that are not necessarily due to its ability to decrease food intake but its specific effects on hepatic lipogenesis related genes (SREBP1a, FAS and SCD-1). The combined effects of Bitam-S to reduce body weight and lipogenic gene expressions, and reduce the deposition of triglyceride in the liver are indicative of a marked improvement in obesity-related non-alcoholic fatty liver disease. Taken together, Bitam-S has potential as a treatment agent for non-alcoholic fatty liver disease and deserves clinical trial in the near future.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Anti-obesity effect of Wild Ginseng extract in ob/ob mice
한국실험동물학회 학술발표대회 논문집
2007 .06
-
Acanthopanax senticosus Reverses Fatty Liver Disease and Hyperglycemia in ob/ob Mice
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2006 .01
-
천연마테차 물추출물의 고지방식이 비만쥐의 체중과 생화학적 변화에 미치는 영향
약학회지
2012 .01
-
Effects of Wild Ginseng on Metabolic Syndrome in 3T3-L1 Adipocyte and ob/ob Mice
한국실험동물학회 학술발표대회 논문집
2009 .08
-
Insulin sensitivity improvement of fermented Korean Red Ginseng (Panax ginseng) mediated by insulin resistance hallmarks in old-aged ob/ob mice
Journal of Ginseng Research
2015 .10
-
Hypoglycemic activity of KHU-3 in Ob/Ob mice
대한약학회 학술대회
2001 .01
-
Inflammation and Signals in Alcoholic and Non-Alcoholic Fatty Liver Disease
한국간담췌외과학회 학술대회지
2014 .04
-
Anti-Metabolic Syndrome Effects of Wild Ginseng in 3T3-L1 Adipocyte and ob/ob mice
고려인삼학회 학술대회
2009 .05
-
Anti-hyperglycemic and Anti-hyperlipidemic Activities of Acanthopanax Senticosus Herbal Acupuncture in C57BL/6J ob/ob Mice
대한침구의학회지
2006 .01
-
Anti-obesity Activity of Diglyceride containing Conjugated Linoleic Acid in C57BL/6J ob/ob Mice
한국실험동물학회 학술발표대회 논문집
2009 .04
-
Insulin sensitivity improvement of fermented Korean red ginseng (Panax ginseng) in old aged ob/ob mice
한국실험동물학회 학술발표대회 논문집
2015 .08
-
The Impact of Weight Changes on Nonalcoholic Fatty Liver Disease in Adult Men with Normal Weight
Korean Journal of Family Medicine
2014 .01
-
Background pathological data in high-fat diet induced obesity mouse and relation to non-alcoholic fatty liver disease
한국실험동물학회 학술발표대회 논문집
2008 .05
-
Background pathological data in high-fat diet induced obesity mouse and relation to non-alcoholic fatty liver disease
한국실험동물학회 학술발표대회 논문집
2008 .05
-
Anti-diabetic effect of broccoli leaf extract on HepG2 cells and ob/ob mice
한국실험동물학회 학술발표대회 논문집
2020 .07
-
UG0712, a Proprietary Ginsenosides Composition, improves Glucose Intolerance in the Obesity Mice (C57BL/6J-ob/ob)
한국실험동물학회 학술발표대회 논문집
2009 .04
-
Ob/ob mouse에서 五精丸이 혈당. 고지혈증, Polyol Pathway 및 항산화작용에 미치는 영향
대한한의학회지
2007 .09
-
Ob/Ob 비만마우스 모델에서 강지환(降脂丸)의 체중감량 효과
대한한의학방제학회지
2017 .01
-
한방 비만 치료 후 간기능 개선을 보인 비알코올성 지방간 환자 1례 보고
한방비만학회지
2007 .01
-
상침자(桑？子)추출물이 ob/ob mouse의 혈당, 혈청 지질, Polyol Pathway, AGE 및 RAGE에 미치는 영향
동의생리병리학회지
2009 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0