메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
Joonho Suh (Seoul National University) Na-Kyung Kim (Seoul National University) Yun-Sil Lee (Seoul National University)
저널정보
대한안면통증구강내과학회 Journal of Oral Medicine and Pain Journal of Oral Medicine and Pain Vol.45 No.4
발행연도
2020.12
수록면
83 - 88 (6page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
Purpose: Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are closely-related transforming growth factor β family members reported to play crucial roles in bone formation. We previously reported that, in contrast to MSTN, GDF11 promotes osteogenesis of vertebrae and limbs. GDF11 has been also reported as an important regulator in tooth development by inducing differentiation of pulp stem cells into odontoblasts for reparative dentin formation. The goal of this study was to investigate the differential roles of GDF11 and MSTN in dental and cranial bone formation.
Methods: Micro-computed tomography analysis was performed on cranial bones, including frontal, parietal, and interparietal bones, and lower incisors of wild-type, Gdf11 knockout (Gdf11 <SUP>-/-</SUP>), and Mstn knockout (Mstn <SUP>-/-</SUP>) mice. Tissue volume, thickness, and mineral density were evaluated for both cranial bone and lower incisors. Lower incisor lengths were also measured. Because Gdf11 <SUP>-/-</SUP> mice die shortly after birth, analysis was performed on newborn (P0) mice.
Results: Compared to those of Mstn -/- mice, cranial bone volume, thickness, and mineral density levels were all significantly diminished in Gdf11 <SUP>-/-</SUP> mice. Tissue mineral density of Gdf11 <SUP>-/-</SUP> mice were also significantly decreased compared to wild-type mice. Likewise, lower incisor length, tissue volume, thickness, and mineral density levels were all significantly reduced in Gdf11 <SUP>-/-</SUP> mice compared to Mstn <SUP>-/-</SUP> mice. Incisor length was also significantly decreased in Gdf11 <SUP>-/-</SUP> mice compared to wild-type mice. Mstn <SUP>-/-</SUP> mice exhibited mildly increased levels of tissue volume, thickness, and density in cranial bone and lower incisor compared to wild-type mice although statistically not significant.
Conclusions: Our findings suggest that GDF11, unlike MSTN, endogenously promotes cranial bone and tooth development.
#Cranial bone #GDF11 #Micro-computed tomography #Myostatin #Tooth

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (28)

참고문헌 신청
Dudas M / 2005 / Tgf-beta superfamily and mouse craniofacial development : interplay of morphogenetic proteins and receptor signaling controls normal formation of the face / Curr Top Dev Biol 66:65~133 google schola McPherron AC / 1999 / Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11 / Nat Genet 22:260~264 google schola McPherron AC / 1997 / Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member / Nature 387:83~90 google schola Suh J / 2020 / GDF11 promotes osteogenesis as opposed to MSTN, and follistatin, a MSTN/GDF11 inhibitor, increases muscle mass but weakens bone / Proc Natl Acad Sci U S A 117:4910~4920 google schola Nicholson EK / 2006 / Biomineralization and adaptive plasticity of the temporomandibular joint in myostatin knockout mice / Arch Oral Biol 51:37~49 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-ECN-0101-2021-515-001451754