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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.12
- 수록면
- 49 - 61 (13page)
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초록· 키워드
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Tetracyclines, which have long been used as broad-spectrum antibiotics, also exhibit a variety of nonantibiotic activities including anti-inflammatory and immunomodulatory properties. Tetracyclines bind to the 30S ribosome of the bacteria and inhibit protein synthesis. Unlike antimicrobial activity, the primary molecular target for the nonantibiotic activity of tetracycline remains to be clarified. Nonetheless, the therapeutic efficacies of tetracyclines, particularly minocycline and doxycycline, have been demonstrated in various animal models of autoimmune disorders, such as multiple sclerosis, rheumatoid arthritis, and asthma. In this study, we summarized the anti-inflammatory and immunomodulatory activities of tetracyclines, focusing on the mechanisms underlying these activities. In addition, we highlighted the on-going or completed clinical trials with reported outcomes.
목차
ABSTRACT
INTRODUCTION
ANTI-INFLAMMATORY AND IMMUNOMODULATORY ACTIVITIES
CLINICAL TRIALS BASED ON ANTI-INFLAMMATORY ANDIMMUNOMODULATORY ACTIVITY OF TETRACYCLINES
CONCLUSION AND PERSPECTIVES
REFERENCES
참고문헌 (72)
참고문헌 신청
Chopra I / 2001 / Tetracycline antibiotics : mode of action, applications, molecular biology, and epidemiology of bacterial resistance / Microbiol Mol Biol Rev 65:232~260
Saleha T / 2018 / Tetracycline : classification, structure activity relationship and mechanism of action as a theranostic agent for infectious lesions-a mini review / Biomed J Sci Tech Res 7:5787~5796
Yong VW / 2004 / The promise of minocycline in neurology / Lancet Neurol 3:744~751
Kim HS / 2009 / Minocycline and neurodegenerative diseases / Behav Brain Res 196:168~179
Santa-Cecília FV / 2019 / The neuroprotective effect of doxycycline on neurodegenerative diseases / Neurotox Res 35:981~986
Saleha T / 2018 / Tetracycline : classification, structure activity relationship and mechanism of action as a theranostic agent for infectious lesions-a mini review / Biomed J Sci Tech Res 7:5787~5796
Yong VW / 2004 / The promise of minocycline in neurology / Lancet Neurol 3:744~751
Kim HS / 2009 / Minocycline and neurodegenerative diseases / Behav Brain Res 196:168~179
Santa-Cecília FV / 2019 / The neuroprotective effect of doxycycline on neurodegenerative diseases / Neurotox Res 35:981~986
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