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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 92 - 92 (1page)
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CRYM (also known as μ-crystallin) is a NADP-regulated thyroid-hormone-binding protein (THBP) expressed in specific tissues including the brain and ear. Although the exact functions and regulatory mechanisms of CRYM are not well understood, it has pivotal roles in cellular differentiation during development, and help maintain thermogenic and metabolic homeostasis, mainly through nuclear receptors that mediate transcriptional activation in the target cells. In the present study, we investigated the effects of CRYM against H2O2-induced neuronal stress in NSC34 cells and against spinal cord ischemia in rabbits. Tat peptide, protein transduction domains (PTDs), and CRYM fusion proteins were prepared to facilitate delivery into cells and across the blood-brain barrier. Intracellula ... 전체 초록 보기
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