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This study was undertaken to clarify the effects of omega-3 fatty acid on endotoxin-induced acute lung injury. Rabbits were randomly assigned to one of four groups. Each group received intravenous infusion of saline only, saline and Escherichia coli endotoxin, omegaven infuison (0.5 mL/kg/hr) and endotoxin, lipoven (0.5 mL/kg/hr) and endotoxin respectively. Infusion of saline was started 0.5 hr before the infusion of saline or endotoxin, and omegaven and lipoven were started 2 hours after endotoxin infusion for 4 hours. The lungs of rabbits were ventilated with 40% oxygen. Mean blood pressure, heart rate, arterial oxygen tension (PaO₂), and peripheral blood leukocyte were recorded. The wet/dry (W/D) weight ratio of lung and lung injury score were measured, and analysis of bronchoalveolar lavage fluid (BALF) was done. Endotoxin decreased PaO₂, and peripheral blood leukocyte and platelet count. And it increased W/D ratio of lung, lung injury score and leukocyte count, percentage of PMN cells, concentration of IL-8 in BALF. Omegaven attenuated all these changes except for peripheral blood leukocyte counts. Omegaven attenuated endotoxin-induced acute lung injury in rabbits mainly by inhibiting neutrophil and IL-8 responses, which may play a central role in endotoxin-related lung injury.
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REFERENCES
참고문헌 (36)
참고문헌 신청
Allen TC / 2014 / Interleukin 8 and acute lung injury / Arch Pathol Lab Med 138:266~269
Augustsson K / 2003 / A prospective study of intake of fish and marine fatty acids and prostate cancer / Cancer Epidemiol Biomarkers Prev 12:64~67
Bernard C / 1992 / Cytokine network and the vessel wall. Insights into septic shock pathogenesis / Eur Cytokine Netw 3:19~33
Bousquet M / 2008 / Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of parkinson's disease / FASEB J 22:1213~1225
Brigham KL / 1986 / Endotoxin and lung injury / Am Rev Respir Dis 133:913~927
Augustsson K / 2003 / A prospective study of intake of fish and marine fatty acids and prostate cancer / Cancer Epidemiol Biomarkers Prev 12:64~67
Bernard C / 1992 / Cytokine network and the vessel wall. Insights into septic shock pathogenesis / Eur Cytokine Netw 3:19~33
Bousquet M / 2008 / Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of parkinson's disease / FASEB J 22:1213~1225
Brigham KL / 1986 / Endotoxin and lung injury / Am Rev Respir Dis 133:913~927
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