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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.48 No.2
- 발행연도
- 2021.6
- 수록면
- 251 - 264 (14page)
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초록· 키워드
오류제보하기
Bovine respiratory syncytial virus (BRSV) and bovine viral diarrhea virus (BVDV) are the main viral contributors to bovine respiratory disease (BRD) with high mortality and morbidity. BRD control measures include vaccination that modulates immunological profiles reflected in blood cells, serum, and body secretions, such as milk. This study evaluated the immune responses to an inactivated BRD vaccine in lactating cows reared in a natural environment on a dairy farm. The cows were intramuscularly inoculated with the vaccine, and serum, blood, and milk were collected pre-and post-vaccination. Our study revealed a prominent increase in BRSV-specific antibodies both in serum and milk, while the change in BVDV-specific antibodies was insignificant. Serum interleukin (IL)-1β and IL-6 levels significantly decreased, but this change was not reflected in milk. Evaluation of pattern recognition receptors (PRRs) via RT-qPCR revealed downregulation of nucleotide-binding oligomerization domain 2 (NOD2). The concentrations of BRSV antibodies, BVDV antibodies, IL-2, and IL-17A in serum and milk were strongly correlated, implying a concurrent influence on both body fluids. Thus, immunological factors modulated as a result of vaccination generally measured in serum were reflected in milk, demonstrating the suitability of milk evaluation as an alternative approach for immunological observations. Furthermore, the correlation between BRSV antibodies and NOD2 and that between BVDV antibodies and toll-like receptor (TLR) 2, TLR3, TLR4, and TLR5 imply the possible role of PRRs for the assessment of the immune response developed in immunized cows reared on the farm.
목차
Abstract
Introduction
Materials and methods
Results and Discussion
Conclusion
References
참고문헌 (44)
참고문헌 신청
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Brodersen BW / 2010 / Bovine respiratory syncytial virus / Veterinary Clinics North America Food Animal Practice 26:323~333
Bryson DG / 1978 / Observations on outbreaks of respiratory disease in housed calves--(2)Pathological and microbiological findings / The Veterinary Record 103:503~509
Cakebread JA / 2015 / Immunoglobulin A in bovine milk: A potential functional food? / Journal of Agricultural and Food Chemistry 63:7311~7316
Carvalho CA / 2014 / Inhibition of Mayaro virus infection by bovine lactoferrin / Virology 452:297~302
Brodersen BW / 2010 / Bovine respiratory syncytial virus / Veterinary Clinics North America Food Animal Practice 26:323~333
Bryson DG / 1978 / Observations on outbreaks of respiratory disease in housed calves--(2)Pathological and microbiological findings / The Veterinary Record 103:503~509
Cakebread JA / 2015 / Immunoglobulin A in bovine milk: A potential functional food? / Journal of Agricultural and Food Chemistry 63:7311~7316
Carvalho CA / 2014 / Inhibition of Mayaro virus infection by bovine lactoferrin / Virology 452:297~302
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