Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data

Hyunsook Choi; Haine Lee; Sang-Soo Lee; Jeonghoon Ahn; Jin Hyun Joh; Moo-Yeol Lee

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자료유형: 학술저널

저자정보: Hyunsook Choi (Medtronic Korea) Haine Lee (Medtronic Korea) Sang-Soo Lee (Medtronic Korea) Jeonghoon Ahn (Ehwa Womans University) Jin Hyun Joh (Kyung Hee University) Moo-Yeol Lee (Chung-Ang University School of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.101 No.1

발행연도: 2021.7

수록면: 20 - 27 (8page)

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Purpose: Drug-coated devices have been widely accepted as one of the most promising therapies for femoropopliteal artery revascularization. A recent meta-analysis showed increased mortality in patients treated with drug-coated devices. We sought to examine the association between mortality and drug-coated devices after the treatment of the femoropopliteal artery based on the Korea national administrative claims data.
Methods: In the National Health Insurance Service database from August 2015 to December 2017, we identified patients with femoropopliteal artery revascularization using percutaneous transluminal angioplasty (PTA), bare metal stents (BMS), drug-coated balloon (DCB), or drug-eluting stents (DES). Kaplan-Meier methods were used to estimate the survival among devices, and log-rank tests were used to evaluate differences between groups. Adjusted hazard ratios (aHRs) were computed using the inverse probability of treatment weightings (IPTW).
Results: There were 1,724 patients (mean age, 70.9 ± 10.7 years; male, 1,350 [78.3%]) included in the analysis. The median follow-up period was 552 days (interquartile range, 404–688 days). There was a difference in IPTW-adjusted mortality risk among device types (26.3% in PTA, 22.1% in BMS, 17.7% in DCB, and 17.8% in DES; P = 0.004). IPTW-adjusted Cox proportional hazard analysis showed that drug-coated devices were associated with decreased all-cause mortality risk (aHR, 0.70; 95% confidence interval, 0.58–0.86).
Conclusion: Our real-world analysis showed that there was no evidence of increased all-cause mortality after femoropopliteal artery revascularization with drug-coated devices compared with non-drug-coated devices.

#Angioplasty #Mortality #Paclitaxel #Peripheral arterial occlusive disease #Stents

참고문헌 (22)

참고문헌 신청

Fowkes FG / 2013 / Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis / Lancet 382:1329~1340

Life Science Intelligence. / Peripheral vascular trends & opportunities: procedure volumes analysis – global

박윤영 / 2015 / National trends for the treatment of peripheral arterial disease in Korea between 2004 and 2013 / Annals of Surgical Treatment and Research 89(6):319~324

Tepe G / 2015 / Angioplasty of femoral-popliteal arteries with drug coated balloons: 5-year follow-up of the THUNDER trial / JACC Cardiovasc Interv 8(1 Pt A):102~108

Ansel GM / 2017 / A quantitative angiographic comparison of restenotic tissue following placement of drug-eluting stents and bare metal stents in symptomatic patients with femoropopliteal disease / J Endovasc Ther 24:499~503

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