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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 202 - 202 (1page)
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Stimulating the metabolic function of BAT, due to special ability to dissipate energy as heat, represent potential therapeutic strategies for increasing energy expenditure and reducing obesity. Mitogen-inducible gene 6, a tumor suppressor gene, is a negative regulator of the EGFR signal. Recently, Mig-6 has an important role in the regulation of cholesterol homeostasis and lipid metabolism in the liver. In previous study, we demonstrated the association between EGFR signaling and NAFLD. However, the roles of Mig-6 in BAT remain poorly understood. We downregulated the expression of Mig-6, using lentivirusmediadted shRNA by transducing Immortalized brown adipocytes. We generated mice enhancing Mig-6 in BAT using a genetic strategy based on the Cre-ROSA recombination. Here, we showed t ... 전체 초록 보기
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