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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 206 - 206 (1page)
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Asb2, ankyrin repeat and SOCS box protein 2 form an E3 ubiquitin ligase complex. Asb2 ubiquitin ligase activity drives the degradation of filamins, which have essential functions in humans [1, 2]. The placenta is a temporary organ that is formed during pregnancy, and normal placentation is important for survival and growth of the fetus [3]. Recent studies have shown that approximately 25-30% of knockout (KO) mice have non-viable offspring, and 68% of knockout lines exhibit placental dysmorphologies [4]. There are very few studies on Asb2, with insufficient researches on its role in placental development. We generated Asb2 knockout mice and investigated Asb2 expression during organogenesis, and identified its role in early embryonic and placental development. The external morphology of KO embryos revealed abnormal phenotypes including growth retardation, peri-cardial effusion, pale color, and especially heart beat defect from E 9.5. Furthermore, Asb2 expression was observed in the heart from E 9.5, indicating that it is specifically expressed during early heart formation and defects, result in embryonic lethality. Histological analysis of E 10.5 KO mouse heart showed malformations such as failure of chamber formation, reduction in ... 전체 초록 보기
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