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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 215 - 215 (1page)
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초록· 키워드
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Background: Avapritinib, a potent inhibitor of KIT and platelet-derived growth factor receptor A tyrosine kinases, has demonstrated substantial clinical activity in gastrointestinal stromal tumors (GIST) which shows significant fibrosis occasionally. The aim of this study was to investigate the anti-fibrotic effects of avapritinib in a preclinical model of scleroderma and to provide a scientific background for clinical studies. Methods: The effects of avapritinib on proliferation of dermal fibroblasts isolated from patients with systemic sclerosis (SSc) were analysed by using real-time live cell imaging system. The anti-fibrotic effects of avapritinib were evaluated in a murine bleomycin-induced skin fibrosis model and compared with that of nintedanib. Skin fibrosis score was measured using dermal thickness on H&E and Masson trichrome-stained tissues. Hydroxyproline content of the whole skin was measured with colorimeteric assay. Transcripts of inflammatory cytokines wer ... 전체 초록 보기
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