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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 774 - 783 (10page)
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The lung has a vital function in gas exchange between the blood and the external atmosphere. It also has a critical role in the immune defense against external pathogens and environmental factors. While the lung is classified as a relatively quiescent organ with little homeostatic turnover, it shows robust regenerative capacity in response to injury, mediated by the resident stem/progenitor cells. During regeneration, regionally distinct epithelial cell populations with specific functions are generated from several different types of stem/progenitor cells localized within four histologically distinguished regions: trachea, bronchi, bronchioles, and alveoli. WNT signaling is one of the key signaling pathways involved in regulating many types of stem/progenitor cells in various organs. In addition to its developmental role in the embryonic and fetal lung, WNT signaling is critical for lung homeostasis and regeneration. In this minireview, we summarize and discuss recent advances in the understanding of the role of WNT signaling in lung regeneration with an emphasis on stem/progenitor cells.
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참고문헌 (67)
참고문헌 신청
Andersson-Sjoland, A. / 2016 / ROS-induced endothelial stress contributes to pulmonary fibrosis through pericytes and Wnt signaling / Lab. Invest 96:206~217
Ardhanareeswaran, K. / 2013 / Lung stem and progenitor cells / Respiration 85:89~95
Barkauskas, C. E. / 2013 / Type 2 alveolar cells are stem cells in adult lung / J. Clin. Invest 123:3025~3036
Barker, N. / 2013 / Lgr proteins in epithelial stem cell biology / Development 140:2484~2494
Basil, M. C. / 2020 / The cellular and physiological basis for lung repair and regeneration : past, present, and future / Cell Stem Cell 26:482~502
Ardhanareeswaran, K. / 2013 / Lung stem and progenitor cells / Respiration 85:89~95
Barkauskas, C. E. / 2013 / Type 2 alveolar cells are stem cells in adult lung / J. Clin. Invest 123:3025~3036
Barker, N. / 2013 / Lgr proteins in epithelial stem cell biology / Development 140:2484~2494
Basil, M. C. / 2020 / The cellular and physiological basis for lung repair and regeneration : past, present, and future / Cell Stem Cell 26:482~502
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