지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 188 - 197 (10page)
이용수
초록· 키워드
오류제보하기
Cells are designed to be sensitive to a myriad of external cues so they can fulfil their individual destiny as part of the greater whole. A number of well-characterised signalling pathways dictate the cell’s response to the external environment and incoming messages. In healthy, well-ordered homeostatic systems these signals are tightly controlled and kept in balance. However, given their powerful control over cell fate, these pathways, and the transcriptional machinery they orchestrate, are frequently hijacked during the development of neoplastic disease. A prime example is the Wnt signalling pathway that can be modulated by a variety of ligands and inhibitors, ultimately exerting its effects through the β-catenin transcription factor and its downstream target genes. Here we focus on the interplay between the three-member family of RUNX transcription factors with the Wnt pathway and how together they can influence cell behaviour and contribute to cancer development. In a recurring theme with other signalling systems, the RUNX genes and the Wnt pathway appear to operate within a series of feedback loops. RUNX genes are capable of directly and indirectly regulating different elements of the Wnt pathway to either strengthen or inhibit the signal. Equally, β-catenin and its transcriptional co-factors can control RUNX gene expression and together they can collaborate to regulate a large number of third party co-target genes.
목차
등록된 정보가 없습니다.
참고문헌 (127)
참고문헌 신청
Akech, J. / 2010 / Runx2association with progression of prostate cancer in patients : mechanisms mediating bone osteolysis and osteoblastic metastatic lesions / Oncogene 29:811~821
Anastas, J. N. / 2013 / WNT signalling pathways as therapeutic targets in cancer / Nat. Rev. Cancer 13:11~26
Andreu, P. / 2008 / A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation / Dev. Biol 324:288~296
Araki, K. / 2005 / Expression of RUNX3 protein in human lung adenocarcinoma : implications for tumor progression and prognosis / Cancer Sci 96:227~231
Banerji, S. / 2012 / Sequence analysis of mutations and translocations across breast cancer subtypes / Nature 486:405~409
Anastas, J. N. / 2013 / WNT signalling pathways as therapeutic targets in cancer / Nat. Rev. Cancer 13:11~26
Andreu, P. / 2008 / A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation / Dev. Biol 324:288~296
Araki, K. / 2005 / Expression of RUNX3 protein in human lung adenocarcinoma : implications for tumor progression and prognosis / Cancer Sci 96:227~231
Banerji, S. / 2012 / Sequence analysis of mutations and translocations across breast cancer subtypes / Nature 486:405~409
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Role of RUNX Family Transcription Factors in DNA Damage Response
Molecules and Cells
2020 .01
-
Post-Translational Regulations of Transcriptional Activity of RUNX2
Molecules and Cells
2020 .01
-
Molecular Mechanism of Runx2-Dependent Bone Development
Molecules and Cells
2020 .01
-
The Roles of RUNX Family Proteins in Development of Immune Cells
Molecules and Cells
2020 .01
-
CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
Molecules and Cells
2020 .01
-
Metabolome-Wide Reprogramming Modulated by Wnt/β-Catenin Signaling Pathway
Journal of Microbiology and Biotechnology
2023 .01
-
Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
Molecules and Cells
2020 .01
-
REGULATION OF β-CATENIN IN THE WNT SIGNALING PATHWAY AND EMT VIA OPTIMAL CONTROL
East Asian Mathematical Journal
2023 .01
-
The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
Molecules and Cells
2020 .01
-
RUNX1 Dosage in Development and Cancer
Molecules and Cells
2020 .01
-
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Molecules and Cells
2022 .12
-
SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway
Molecules and Cells
2018 .09
-
Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
2020 .01
-
Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
-
Non-Polar Myxococcus fulvus KYC4048 Metabolites Exert Anti-Proliferative Effects via Inhibition of Wnt/β-Catenin Signaling in MCF-7 Breast Cancer Cells
Journal of Microbiology and Biotechnology
2021 .01
-
The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Molecules and Cells
2020 .01
-
RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
-
Involvement of RUNX and BRD Family Members in Restriction Point
Molecules and Cells
2019 .01
-
대장상피세포 속 Wnt 신호 경로에 대한 C. difficile 톡신A의 영향
생명과학회지
2018 .09
-
MicroRNA-766-3p Inhibits Tumour Progression by Targeting Wnt3a in Hepatocellular Carcinoma
Molecules and Cells
2018 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0