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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 830 - 841 (12page)
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Recent studies have indicated that microRNAs (miRNAs) play an important role in hepatocellular carcinoma (HCC) progression. In this study, we showed that miR-766-3p was decreased in approximately 72% of HCC tissues and cell lines, and its low expression level was significantly correlated with tumour size, TNM stage, metastasis, and poor prognosis in HCC. Ectopic miR-766-3p expression inhibited HCC cell proliferation, colony formation, migration and invasion. In addition, we showed that miR-766-3p repressed Wnt3a expression. A luciferase reporter assay revealed that Wnt3a was a direct target of miR-766-3p, and an inverse correlation between miR-766-3p and Wnt3a expression was observed. Moreover, Wnt3a up-regulation reversed the effects of miR-766-3p on HCC progression. In addition, our study showed that miR-766-3p up-regulation decreased the nuclear β-catenin level and expression of Wnt targets (TCF1 and Survivin) and reduced the level of MAP protein regulator of cytokinesis 1 (PRC1). However, these effects of miR-766-3p were reversed by Wnt3a up-regulation. In addition, PRC1 upregulation increased the nuclear β-catenin level and protein expression of TCF1 and Survivin. iCRT3, which disrupts the β-catenin-TCF4 interaction, repressed the TCF1, Survivin and PRC1 protein levels. Taken together, our results suggest that miR-766-3p down-regulation promotes HCC cell progression, probably by targeting the Wnt3a/PRC1 pathway, and miR-766-3p may serve as a potential therapeutic target in HCC.
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참고문헌 (30)
참고문헌 신청
Aushev, V.N. / 2018 / Novel predictors of breast cancer survival derived from miRNA activity analysis / Clin. Cancer Res. 24:581~591
Bracken, C.P. / 2015 / Networkbased approaches to understand the roles of miR-200 and other microRNAs in cancer / Cancer Res. 75:2594~2599
Cancer Genome Atlas Research Network / 2017 / Cancer Genome Atlas Research Network. Comprehensive and integrative genomic characterization of hepatocellular carcinoma / Cell 169:1327~1341
Chen, J. / 2016 / The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/${\beta}$ -catenin signalling pathway / Gut 59:1522~1534
Chen, C. / 2017 / DNA-methylationmediated repression of miR-766-3p promotes cell proliferation via targeting SF2 expression in renal cell carcinoma / Int. J. Cancer. 141:1867~1878
Bracken, C.P. / 2015 / Networkbased approaches to understand the roles of miR-200 and other microRNAs in cancer / Cancer Res. 75:2594~2599
Cancer Genome Atlas Research Network / 2017 / Cancer Genome Atlas Research Network. Comprehensive and integrative genomic characterization of hepatocellular carcinoma / Cell 169:1327~1341
Chen, J. / 2016 / The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/
Chen, C. / 2017 / DNA-methylationmediated repression of miR-766-3p promotes cell proliferation via targeting SF2 expression in renal cell carcinoma / Int. J. Cancer. 141:1867~1878
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