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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 153 - 159 (7page)
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Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder. NF1 patients are predisposed to formation of several type solid tumors as well as to juvenile myelomonocytic leukemia. Loss of NF1 results in dysregulation of MAPK, PI3K and other signaling cascades, to promote cell proliferation and to inhibit cell apoptosis. The RUNX1 gene is associated with stem cell function in many tissues, and plays a key role in the fate of stem cells. Aberrant RUNX1 expression leads to context-dependent tumor development, in which RUNX1 may serve as a tumor suppressor or an oncogene in specific tissue contexts. The co-occurrence of mutation of NF1 and RUNX1 is detected rarely in several cancers and signaling downstream of RAS-MAPK can alter RUNX1 function. Whether aberrant RUNX1 expression contributes to NF1-related tumorigenesis is not fully understood. This review focuses on the role of RUNX1 in NF1-related tumors and blood disorders, and in sporadic cancers.
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참고문헌 (66)
참고문헌 신청
Akech, J. / 2010 / Runx2association with progression of prostate cancer in patients : mechanisms mediating bone osteolysis and osteoblastic metastatic lesions / Oncogene 29:811~821
Al Mugairi, A. / 2019 / Isolated bone marrow non-langerhans cell histiocytosis preceding RUNX1-Mutated acute myeloid leukemia : case report and literature review / Am. J. Clin. Pathol 151:638~646
Banerji, S. / 2012 / Sequence analysis of mutations and translocations across breast cancer subtypes / Nature 486:405~409
Bejar, R. / 2011 / Clinical effect of point mutations in myelodysplastic syndromes / N. Engl. J. Med 364:2496~2506
Bell, D. / 2011 / Integrated genomic analyses of ovarian carcinoma / Nature 474:609~615
Al Mugairi, A. / 2019 / Isolated bone marrow non-langerhans cell histiocytosis preceding RUNX1-Mutated acute myeloid leukemia : case report and literature review / Am. J. Clin. Pathol 151:638~646
Banerji, S. / 2012 / Sequence analysis of mutations and translocations across breast cancer subtypes / Nature 486:405~409
Bejar, R. / 2011 / Clinical effect of point mutations in myelodysplastic syndromes / N. Engl. J. Med 364:2496~2506
Bell, D. / 2011 / Integrated genomic analyses of ovarian carcinoma / Nature 474:609~615
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CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
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The Roles of RUNX Family Proteins in Development of Immune Cells
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Role of RUNX Family Transcription Factors in DNA Damage Response
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Molecular Mechanism of Runx2-Dependent Bone Development
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RUNX1 Dosage in Development and Cancer
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Post-Translational Regulations of Transcriptional Activity of RUNX2
Molecules and Cells
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RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
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Involvement of RUNX and BRD Family Members in Restriction Point
Molecules and Cells
2019 .01
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K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
Molecules and Cells
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
2020 .01
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
Genes & Genomics
2024 .04
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Differential Regulation of NF-κB Signaling during Human Cytomegalovirus Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
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Ampelopsin alleviates sevoflurane-induced cognitive dysfunction by mediating NF-κB pathway in aged rats
Genes & Genomics
2020 .01
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
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