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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 145 - 152 (8page)
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초록· 키워드
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RUNX1 plays an important role in the regulation of normal hematopoiesis. RUNX1 mutations are frequently found and have been intensively studied in hematological malignancies. Germline mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). Somatic mutations of RUNX1 are observed in various types of hematological malignancies, such as AML, acute lymphoblastic leukemia (ALL), myelodysplastic syndromes (MDS), myeloproliferative neoplasm (MPN), chronic myelomonocytic leukemia (CMML), and congenital bone marrow failure (CBMF). Here, we systematically review the clinical and molecular characteristics of RUNX1 mutations, the mechanisms of pathogenesis caused by RUNX1 mutations, and potential therapeutic strategies to target RUNX1-mutated cases of hematological malignancies.
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참고문헌 (85)
참고문헌 신청
Antony-Debre, I. / 2016 / Somatic mutations associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia / Leukemia 30:999~1002
Baer, C. / 2018 / Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2 / Haematologica 103:e348~e350
Beer, P. A. / 2010 / Two routes to leukemic transformation after a JAK2 mutationpositive myeloproliferative neoplasm / Blood 115:2891~2900
Bejar, R. / 2012 / Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes / J. Clin. Oncol 30:3376~3382
Branford, S. / 2018 / Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease / Blood 132:948~961
Baer, C. / 2018 / Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2 / Haematologica 103:e348~e350
Beer, P. A. / 2010 / Two routes to leukemic transformation after a JAK2 mutationpositive myeloproliferative neoplasm / Blood 115:2891~2900
Bejar, R. / 2012 / Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes / J. Clin. Oncol 30:3376~3382
Branford, S. / 2018 / Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease / Blood 132:948~961
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
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RUNX1 Dosage in Development and Cancer
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Role of RUNX Family Transcription Factors in DNA Damage Response
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The Roles of RUNX Family Proteins in Development of Immune Cells
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
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Post-Translational Regulations of Transcriptional Activity of RUNX2
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Molecular Mechanism of Runx2-Dependent Bone Development
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The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
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RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
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Involvement of RUNX and BRD Family Members in Restriction Point
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
Genes & Genomics
2024 .04
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
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K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
Molecules and Cells
2020 .01
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
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RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
Molecules and Cells
2023 .04
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Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Molecules and Cells
2019 .01
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
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