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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 945 - 952 (8page)
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Hypoxia induces the expression of several genes through the activation of a master transcription factor, hypoxia-inducible factor (HIF)-1α. This study shows that hypoxia strongly induced the expression of two carboxypeptidases (CP), CPA4 and CPE, in an HIF-1α-dependent manner. The hypoxic induction of CPA4 and CPE gene was accompanied by the recruitment of HIF-1α and upregulation in the active histone modification, H3K4me3, at their promoter regions. The hypoxic responsiveness of CPA4 and CPE genes was observed in human adipocytes, human adipose-derived stem cells, and human primary fibroblasts but not mouse primary adipocyte progenitor cells. CPA4 and CPE have been identified as secreted exopeptidases that degrade and process other secreted proteins and matrix proteins. This finding suggests that hypoxia changes the microenvironment of the obese hypoxic adipose tissue by inducing the expression of not only adipokines but also peptidases such as CPA4 and CPE.
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참고문헌 (24)
참고문헌 신청
Baboota, R. K. / 2015 / Microarray based gene expression analysis of murine brown and subcutaneous adipose tissue : significance with human / PLoS One 10:e0127701
Cawley, N. X. / 2016 / Carboxypeptidase E and secretogranin III coordinately facilitate efficient sorting of proopiomelanocortin to the regulated secretory pathway in AtT20 cells / Mol. Endocrinol 30:37~47
Che, F. Y. / 2001 / Identification of peptides from brain and pituitary of Cpefat/Cpefat mice / Proc. Natl. Acad. Sci. U. S. A 98:9971~9976
Chusyd, D. E. / 2016 / Relationships between rodent white adipose fat pads and human white adipose fat depots / Front. Nutr 3:10
Freshney, R. I. / 2000 / Culture of Animal Cells: A Manual of Basic Technique / Wiley
Cawley, N. X. / 2016 / Carboxypeptidase E and secretogranin III coordinately facilitate efficient sorting of proopiomelanocortin to the regulated secretory pathway in AtT20 cells / Mol. Endocrinol 30:37~47
Che, F. Y. / 2001 / Identification of peptides from brain and pituitary of Cpefat/Cpefat mice / Proc. Natl. Acad. Sci. U. S. A 98:9971~9976
Chusyd, D. E. / 2016 / Relationships between rodent white adipose fat pads and human white adipose fat depots / Front. Nutr 3:10
Freshney, R. I. / 2000 / Culture of Animal Cells: A Manual of Basic Technique / Wiley
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