지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제12호
- 발행연도
- 2020.1
- 수록면
- 1,810 - 1,818 (9page)
이용수
초록· 키워드
오류제보하기
Inhibitor K562 (IK) protein was first isolated from the culture medium of K562 cells, a leukemia cell line, and is an inhibitory regulator of interferon-γ-induced major histocompatibility complex class II expression. Recently, exogenous truncated IK (tIK) protein showed potential as a therapeutic agent for inflammation-related diseases. In this study, we designed a novel putative anti-inflammatory peptide derived from tIK protein based on homology modeling of the human interleukin-10 (hIL-10) structure, and investigated whether the peptide exerted inhibitory effects against proinflammatory cytokines such as IL-17 and tumor necrosis factor-α (TNF-α). The peptide contains key residues involved in binding hIL-10 to the IL-10 receptor, and exerted strong inhibitory effects on IL- 17 (43.8%) and TNF-α (50.7%). In addition, we used circular dichroism spectroscopy to confirm that the peptide is usually present in a random coil configuration in aqueous solution. In terms of toxicity, the peptide was found to be biologically safe. The mechanisms by which the short peptide derived from human tIK protein exerts inhibitory effects against IL-17 and TNF-α should be explored further. We also evaluated the feasibility of using this novel peptide in skincare products.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Holling TM / 2004 / Function and regulation of MHC class II molecules in T-lymphocytes : of mice and men / Hum. Immunol 65:282~290
Neefjes J / 2011 / Towards a systems understanding of MHC class I and MHC class II antigen presentation / Nat. Rev. Immunol 11:823~836
Gaspari AA / 1988 / Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in haptenspecific Th1 clones / J. Immunol 141:2216~2220
Frasca L / 1998 / Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance / Kidney Int 53:679~689
Bal V / 1990 / Antigen presentation by keratinocytes induces tolerance in human T cells / Eur. J. Immunol 20:1893~1897
Neefjes J / 2011 / Towards a systems understanding of MHC class I and MHC class II antigen presentation / Nat. Rev. Immunol 11:823~836
Gaspari AA / 1988 / Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in haptenspecific Th1 clones / J. Immunol 141:2216~2220
Frasca L / 1998 / Interferon-gamma-treated renal tubular epithelial cells induce allospecific tolerance / Kidney Int 53:679~689
Bal V / 1990 / Antigen presentation by keratinocytes induces tolerance in human T cells / Eur. J. Immunol 20:1893~1897
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
인간유방암 MDA-MB-231세포에서 peptide H에 의한 TNFα 발현 억제
미생물학회지
2015 .09
-
Antioxidant and Anti-Inflammatory Effects of NCW Peptide from Clam Worm (Marphysa sanguinea)
Journal of Microbiology and Biotechnology
2020 .01
-
홍어껍질을 이용한 고기능성 콜라겐 펩타이드 소재 개발
한국환경과학회지
2016 .04
-
Efficient Interleukin-21 Production by Optimization of Codon and Signal Peptide in Chinese Hamster Ovarian Cells
Journal of Microbiology and Biotechnology
2019 .01
-
Structure-catalytic activity correlation in peptide-programmable nanoparticle superstructures
한국진공학회 학술발표회초록집
2019 .08
-
Designing Signal Peptides for Efficient Periplasmic Expression of Human Growth Hormone in Escherichia coli
Journal of Microbiology and Biotechnology
2017 .01
-
Bactericidal Activity and Mechanism of Action of Novel Antimicrobial Peptide SHP20 and Its Analog Peptides against Pseudomonas aeruginosa
한국미생물학회 학술대회논문집
2022 .10
-
Antimicrobial Cyclic Peptides for Plant Disease Control
The Plant Pathology Journal
2015 .03
-
Antimicrobial Peptides from Lactobacillus plantarum UTNGt2 Prevent Harmful Bacteria Growth on Fresh Tomatoes
Journal of Microbiology and Biotechnology
2019 .01
-
Antimicrobial Activity and Action of Mechanism of Antimicrobial Peptide and Its Analog Peptides against Acinetobacter baumannii and Staphylococcus aureus
한국미생물학회 학술대회논문집
2019 .04
-
Neuropeptide Regulation of Signaling and Behavior in the BNST
Molecules and Cells
2015 .01
-
Enhancement of the Solubility of Recombinant Proteins by Fusion with a Short-disordered Peptide
한국미생물학회 학술대회논문집
2022 .10
-
Enhancement of the Solubility of Recombinant Proteins by Fusion with a Short-disordered Peptide
한국미생물학회 학술대회논문집
2022 .10
-
Development of a Novel Short Synthetic Antibacterial Peptide Derived from the Swallowtail Butterfly Papilio xuthus Larvae
Journal of Microbiology and Biotechnology
2020 .01
-
MALDI-TOF Analysis of Binding between DNA and Peptides Containing Lysine and Tryptophan
Mass Spectrometry Letters
2015 .09
-
Understanding the Roles of Host Defense Peptides in Immune Modulation: From Antimicrobial Action to Potential as Adjuvants
Journal of Microbiology and Biotechnology
2023 .03
-
Peptide fragmentation caused by primary ion beam
한국진공학회 학술발표회초록집
2016 .08
-
Design and Engineering of Antimicrobial Peptides Based on LPcin- YK3, an Antimicrobial Peptide Derivative from Bovine Milk
Journal of Microbiology and Biotechnology
2018 .01
-
Antimicrobial Activity of Antimicrobial Peptide LPcin-YK3 Derived from Bovine Lactophoricin
Journal of Microbiology and Biotechnology
2018 .01
-
Integrated Thermochemical Approach to Collision-Induced Dissociation Process of Peptides
Mass Spectrometry Letters
2021 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0