지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 307 - 316 (10page)
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초록· 키워드
오류제보하기
Convalescent plasma has been used for decades to prevent and treat a wide range of infectious diseases for which no specific treatment is available. The use of convalescent plasma involves transfusing plasma collected from patients who have recovered from a viral illness, in an attempt to transfer virus-neutralizing antibodies and confer passive immunity. In addition to the antiviral mechanisms of neutralizing antibodies, the immunomodulatory effects of plasma components could have benefits. Several small and large-scale studies have shown the effects of convalescent plasma for the treatment of severe coronavirus disease 2019 (COVID-19). In addition to transfusion-related side effects, unexpected side effects such as antibody-dependent enhancement (ADE) may occur during convalescent plasma therapy, but early safety studies have not found any cases of ADE among more than 5,000 participants. With historical precedents and recent clinical studies, convalescent plasma therapy should be considered as a candidate therapy for COVID-19 given the limited effectiveness of antiviral drugs and lack of a vaccine. A system to secure safe collection and use of convalescent plasma should be developed as a response to the pandemic. Further clinical trials should be conducted to determine the safety and efficacy of convalescent plasma therapy concurrently with its clinical use.
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참고문헌 (40)
참고문헌 신청
World Health Organization (WHO) / Coronavirus disease (COVID-19) pandemic
Guan WJ / 2020 / Clinical characteristics of coronavirus disease 2019 in China / N Engl J Med 382:1708~1720
강승지 / 2020 / Age-Related Morbidity and Mortality among Patients with COVID-19 / Infection and Chemotherapy 52(2):154~164
Kim Sun Bean / 2020 / Interim Guidelines on Antiviral Therapy for COVID-19 / Infection and Chemotherapy 52(2):281~304
Beigel JH / 2020 / Remdesivir for the treatment of Covid-19 - preliminary report / N Engl J Med :2007764
Guan WJ / 2020 / Clinical characteristics of coronavirus disease 2019 in China / N Engl J Med 382:1708~1720
강승지 / 2020 / Age-Related Morbidity and Mortality among Patients with COVID-19 / Infection and Chemotherapy 52(2):154~164
Kim Sun Bean / 2020 / Interim Guidelines on Antiviral Therapy for COVID-19 / Infection and Chemotherapy 52(2):281~304
Beigel JH / 2020 / Remdesivir for the treatment of Covid-19 - preliminary report / N Engl J Med :2007764
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