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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 169 - 178 (10page)
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초록· 키워드
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Background: The occurrence of multidrug-resistant (MDR) bacteremia in ventilated patients may be associated with a high mortality rate. We evaluated whether Sequential Organ Failure Assessment (SOFA) score on the day of bacteremia could predict 90-day mortality in these patients. Methods: Data were obtained retrospectively from 202 patients (male, 60.4%; median age, 64 years) hospitalized at a single university-affiliated tertiary care hospital. All adult patients who had were ventilated and had one of the following six MDR bacteremias between March 2011 and February 2018 were enrolled: methicillin-resistant Staphylococcus aureus, extended- spectrum β-lactamase-producing Gram-negative bacteria (Escherichia coli and Klebsiella pneumonia), carbapenem-resistant Gram-negative rods (Acinetobacter baumannii and Pseudomonas aeruginosa), or vancomycin-resistant Enterococcus faecium. Results: The overall 90-day mortality rate after the day of bacteremia was 59.9%. The areas under the receiver operating characteristic curves for the SOFA and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were 0.732 (95% confidence interval [CI], 0.666 to 0.792; P<0.001) and 0.662 (95% CI, 0.593 to 0.727; P<0.001), respectively, with no difference between the two (P=0.059). Also, the cutoff value of the SOFA score was 9 (based on Youden’s index). Multivariate Cox regression analysis showed that this cut-off value was significantly associated with higher mortality rate (hazard ratio, 2.886; 95% CI, 1.946 to 4.221; P<0.001). Conclusions: SOFA score measured on the day of bacteremia may be a useful prognostic indicator of 90-day mortality in ventilated patients with MDR bacteremia.
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참고문헌 (21)
참고문헌 신청
Pulcini C / 2008 / Design of a ‘day 3 bundle’ to improve the reassessment of inpatient empirical antibiotic prescriptions / J Antimicrob Chemother 61:1384~1388
Levy-Hara G / 2011 / "Ten commandments"for the appropriate use of antibiotics by the practicing physician in an outpatient setting / Front Microbiol 2:230
Levy Hara G / 2016 / Ten key points for the appropriate use of antibiotics in hospitalised patients : a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy / Int J Antimicrob Agents 48:239~246
Magill SS / 2014 / Multistate point-prevalence survey of health care-associated infections / N Engl J Med 370:1198~1208
Magiorakos AP / 2012 / Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria : an international expert proposal for interim standard definitions for acquired resistance / Clin Microbiol Infect 18:268~281
Levy-Hara G / 2011 / "Ten commandments"for the appropriate use of antibiotics by the practicing physician in an outpatient setting / Front Microbiol 2:230
Levy Hara G / 2016 / Ten key points for the appropriate use of antibiotics in hospitalised patients : a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy / Int J Antimicrob Agents 48:239~246
Magill SS / 2014 / Multistate point-prevalence survey of health care-associated infections / N Engl J Med 370:1198~1208
Magiorakos AP / 2012 / Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria : an international expert proposal for interim standard definitions for acquired resistance / Clin Microbiol Infect 18:268~281
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