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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 10 (10page)
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Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) infection is associated with high mortality. One of the strategies to reduce the mortality in patients with CRAB infections is to use intravenous colistin early but the effect of this strategy has not been proven. Therefore, we investigated the association of early colistin therapy with 28-day mortality in patients with CRAB bacteremia. Methods: This retrospective multicenter propensity score-matching analysis was conducted in the Korea by reviewing the medical records of adult patients with CRAB bacteremia between January 2012 and March 2015. Early colistin therapy was defined as intravenous colistin administration for > 48 hours within five days after the blood culture collection. To identify the risk factors associated with the 28-day mortality in CRAB bacteremia, the clinical variables of the surviving patients were compared to those of the deceased patients. Results: Of 303 enrolled patients, seventy-six (25.1%) patients received early colistin therapy. The 28-day mortality was 61.4% (186/303). Fatal or rapidly-fatal McCabe classifications, intensive care unit admission, Sequential Organ Failure Assessment scores ≥ 8, vasopressor use, and acute kidney injury were statistically independent poor prognostic factors. Catheter- related infection and early colistin therapy (adjusted odds ratio [aOR], 0.45; 95% confidence interval [CI], 0.21–0.94) were independent favorable prognostic factors associated with 28- day mortality in patients with CRAB bacteremia. Early colistin therapy was still significantly associated with lower 28-day mortality in the propensity score-matching analysis (aOR, 0.31; 95% CI, 0.11–0.88). Conclusion: This study suggests that early colistin therapy might help reduce the mortality of patients with CRAB bacteremia.
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참고문헌 (18)
참고문헌 신청
김도균 / 2017 / Increasing Resistance to Extended-Spectrum Cephalosporins, Fluoroquinolone, and Carbapenem in Gram-Negative Bacilli and the Emergence of Carbapenem Non-Susceptibility in Klebsiella pneumoniae: Analysis of Korean Antimicrobial Resistance Monitoring System (KARMS) Data From 2013 to 2015 / Annals of Laboratory Medicine 37(3):231~239
Kim T / 2018 / Natural prognosis of carbapenem-resistant Acinetobacter baumannii bacteremia in patients who did not receive appropriate antibiotic treatment : a retrospective multicenter study in Korea / Medicine(Baltimore) 97(43):e12984
Daitch V / 2018 / Secular trends in the appropriateness of empirical antibiotic treatment in patients with bacteremia : a comparison between three prospective cohorts / Eur J Clin Microbiol Infect Dis 37(3):455~462
Al-Dorzi HM / 2015 / Impact of empirical antimicrobial therapy on the outcome of critically ill patients with Acinetobacter bacteremia / Ann Thorac Med 10(4):256~262
Poirel L / 2017 / Polymyxins : antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes / Clin Microbiol Rev 30(2):557~596
Kim T / 2018 / Natural prognosis of carbapenem-resistant Acinetobacter baumannii bacteremia in patients who did not receive appropriate antibiotic treatment : a retrospective multicenter study in Korea / Medicine(Baltimore) 97(43):e12984
Daitch V / 2018 / Secular trends in the appropriateness of empirical antibiotic treatment in patients with bacteremia : a comparison between three prospective cohorts / Eur J Clin Microbiol Infect Dis 37(3):455~462
Al-Dorzi HM / 2015 / Impact of empirical antimicrobial therapy on the outcome of critically ill patients with Acinetobacter bacteremia / Ann Thorac Med 10(4):256~262
Poirel L / 2017 / Polymyxins : antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes / Clin Microbiol Rev 30(2):557~596
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