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자료유형
학술저널
저자정보
정승호 (연세대학교 마취통증의학교실) 나성원 (연세대학교) 김혜빈 (연세의대 마취통증의학과) 주혜지 (연세의대 마취통증의학과) 김정민 (연세대학교)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제35권 제3호
발행연도
2020.1
수록면
197 - 204 (8page)

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Background: Although the use of volatile sedatives in the intensive care unit (ICU) is increasing in Europe, it remains infrequent in Asia. Therefore, there are no clinical guidelines available. This study investigates the proper initial concentration of sevoflurane, a volatile sedative that induces a Richmond agitation-sedation scale (RASS) score of ?2 to ?3, in patients who underwent head and neck surgery with tracheostomy. We also compared the amount of postoperative opioid consumption between volatile and intravenous (IV) sedation. Methods: We planned a prospective study to determine the proper initial sevoflurane concentration and a retrospective analysis to compare postoperative opioid consumption between volatile sedation and propofol sedation. Patients scheduled for head and neck surgery with tracheostomy and subsequent postoperative sedation in the ICU were enrolled. Results: In this prospective study, the effective dose 50 (ED50) of initial end-tidal sevoflurane concentration was 0.36% (95% confidence interval [CI], 0.20 to 0.60%), while the ED 95 was 0.69% (95% CI, 0.60 to 0.75%) based on isotonic regression methods. In this retrospective study, remifentanil consumption during postoperative sedation was significantly lower in the sevoflurane group (2.52±1.00 μg/kg/hr, P=0.001) than it was in the IV propofol group (3.66±1.30 μg/kg/hr). Conclusions: We determined the proper initial end-tidal concentration setting of sevoflurane for patients with tracheostomy who underwent head and neck surgery. Postoperative sedation with sevoflurane appears to be a valid and safe alternative to IV sedation with propofol.

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