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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1,288 - 1,290 (3page)
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초록· 키워드
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The non-small cell lung cancer with activating epidermal growth factor receptor (EGFR) mutation eventually acquires resistant to either first or second-generation EGFR tyrosine kinase inhibitor (TKI). As the following option, targeting EGFR T790M with third-generation EGFR TKI is now established as a standard treatment option. In this study, we are reporting the first case of resistance mechanism to the novel third-generation EGFR TKI, lazertinib, which showed promising clinical efficacy in phase 1-2 study. The patients showed resistance to the treatment by acquiring the additional EGFR C797S mutation in cis which is also confirmed from the patient-derived cell lines.
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등록된 정보가 없습니다.
참고문헌 (4)
참고문헌 신청
Sequist LV / 2011 / Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors / Sci Transl Med 3:75ra26
Ahn MJ / 2019 / Lazertinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer : results from the dose escalation and dose expansion parts of a first-in-human, open-label, multicentre, phase 1-2 study / Lancet Oncol 20:1681~1690
Shin HT / 2017 / Prevalence and detection of low-allele-fraction variants in clinical cancer samples / Nat Commun 8:1377
Oxnard GR / 2018 / Assessment of resistance mechanisms and clinical implications in patients with EGFR T790M-positive lung cancer and acquired resistance to osimertinib / JAMA Oncol 4:1527~1534
Ahn MJ / 2019 / Lazertinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer : results from the dose escalation and dose expansion parts of a first-in-human, open-label, multicentre, phase 1-2 study / Lancet Oncol 20:1681~1690
Shin HT / 2017 / Prevalence and detection of low-allele-fraction variants in clinical cancer samples / Nat Commun 8:1377
Oxnard GR / 2018 / Assessment of resistance mechanisms and clinical implications in patients with EGFR T790M-positive lung cancer and acquired resistance to osimertinib / JAMA Oncol 4:1527~1534
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