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논문 기본 정보

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학술저널
저자정보
Yoon Young Ahn (Department of Laboratory Medicine Soonchunhyang University Cheonan Hospital Soonchunhyang Universit) Lee Yong-Wha (Department of Laboratory Medicine and Genetics Soonchunhyang University Bucheon Hospital Soonchunhy) Kim Sollip (Department of Laboratory Medicine Inje University Ilsan Paik Hospital Goyang Korea) Lee Kyunghoon (Department of Laboratory Medicine Seoul National University Bundang Hospital and College of Medicin) Park Hyung-Doo (Department of Laboratory Medicine and Genetics Samsung Medical Center Sungkyunkwan University Schoo) Chun Sail (Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center S) Min Won-Ki (Department of Laboratory Medicine University of Ulsan College of Medicine and Asan Medical Center S)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제4호
발행연도
2021.1
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366 - 371 (6page)

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Background: Total cholesterol concentration measurement is important in the diagnosis of dyslipidemia and evaluation of cardiovascular disease risk factors. Measurement reliability for obtaining an accurate total cholesterol concentration requires procedure standardization. We evaluated the standardization status for total cholesterol concentration measurement through Korean external quality assessment (EQA) data analysis. Methods: This study involved 1,670 laboratories that participated in the EQA of total cholesterol concentration measurements in 2019 for 32 products from different manufacturers. The target concentrations of three quality control (QC) materials (samples A, B, and C) were measured using the reference method and compared with EQA data. The performance criteria for total cholesterol concentration measurement were based on the National Cholesterol Education Program guidelines, with ±3% inaccuracy. Results: The target values and inaccuracies of the QC material based on the reference method measurements were 254.65±7.64, 108.30±3.25, and 256.29±7.69 mg/dL (6.59±0.20, 2.80±0.08, and 6.63±0.20 mmol/L) for samples A, B, and C, respectively. The performance criteria were not met in 42.7% laboratories for sample A, 68.4% of laboratories for sample B, and 38.0% laboratories for sample C. Conclusions: Despite significant efforts to accurately measure total cholesterol concentrations, further actions are needed for measurement standardization. Manufacturers reporting values that differ from target values should check calibrator traceability; additional efforts to accurately measure total cholesterol concentrations are required for laboratories that use products from these manufacturers.
#Inaccuracy #Total cholesterol #External quality assessment #Standardization

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참고문헌 (13)

참고문헌 신청
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) / 2002 / Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report / Circulation 106:3143~3421 google schola Cholesterol Reference Method Laboratory Network / Total cholesterol certification protocol for manufacturers google schola Miller WG / 2009 / The role of proficiency testing in achieving standardization and harmonization between laboratories / Clin Biochem 42:232~235 google schola Kim Sollip / 2021 / Schemes and Performance Evaluation Criteria of Korean Association of External Quality Assessment (KEQAS) for Improving Laboratory Testing / Annals of Laboratory Medicine 41(2):230~239 dbpia Kim H / 2020 / Status of quality control for laboratory tests of medical institutions in Korea: analysis of 10 years of data on external quality assessment participation / Healthcare (Basel) 8:75 google schola

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