지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한비만학회 Journal of Obesity & Metabolic Syndrome Journal of Obesity & Metabolic Syndrome Vol.30 No.2
- 발행연도
- 2021.1
- 수록면
- 173 - 177 (5page)
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초록· 키워드
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Background: The role of interleukin-10 (IL-10) in humans is controversial because IL-10 has been proposed to exhibit both pro- and anti-inflammatory effects. We aimed to determine the relationships between the changes in these parameters in obese individuals participating in a weight-reduction program. Methods: We measured cardiometabolic parameters including lipid profile and serum IL-10 concentration before and after completion of a 12-week weight-reduction program in 63 non-diabetic obese subjects with a body mass index ≥27 kg/m2 who had comorbid hypertension or dyslipidemia. All the participants were provided with individual intervention sessions designed to implement lifestyle modifications and administered 120 mg orlistat three times daily for 12 weeks. The relationships between changes in serum IL-10 concentration and changes in cardiometabolic risk factors were analyzed. Results: Changes in serum IL-10 concentration were significantly negatively correlated with changes in total cholesterol (r=−0.377), high-density lipoprotein cholesterol (HDL-C; r=−0.377), and low-density lipoprotein cholesterol (LDL-C; r=−0.278) concentrations. However, there were no correlations between changes in serum IL-10 concentration and changes in other cardiometabolic parameters. Conclusion: Serum IL-10 concentration can increase as serum total cholesterol decreases. Additional studies are needed to explore the mechanisms linking changes in serum IL-10 with serum LDL-C and HDL-C concentrations.
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참고문헌 (20)
참고문헌 신청
Mosser DM / 2008 / Interleukin-10 : new perspectives on an old cytokine / Immunol Rev 226:205~218
Mallat Z / 1999 / Expression of interleukin-10 in advanced human atherosclerotic plaques : relation to inducible nitric oxide synthase expression and cell death / Arterioscler Thromb Vasc Biol 19:611~616
Esposito K / 2003 / Association of low interleukin-10 levels with the metabolic syndrome in obese women / J Clin Endocrinol Metab 88:1055~1058
Straczkowski M / 2005 / Plasma interleukin-10 concentration is positively related to insulin sensitivity in young healthy individuals / Diabetes Care 28:2036~2037
Jung SH / 2008 / Effect of weight loss on some serum cytokines in human obesity : increase in IL-10 after weight loss / J Nutr Biochem 19:371~375
Mallat Z / 1999 / Expression of interleukin-10 in advanced human atherosclerotic plaques : relation to inducible nitric oxide synthase expression and cell death / Arterioscler Thromb Vasc Biol 19:611~616
Esposito K / 2003 / Association of low interleukin-10 levels with the metabolic syndrome in obese women / J Clin Endocrinol Metab 88:1055~1058
Straczkowski M / 2005 / Plasma interleukin-10 concentration is positively related to insulin sensitivity in young healthy individuals / Diabetes Care 28:2036~2037
Jung SH / 2008 / Effect of weight loss on some serum cytokines in human obesity : increase in IL-10 after weight loss / J Nutr Biochem 19:371~375
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