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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Onychomycosis is a common nail fungal infection that affects the nail bed, plate, and matrix. It accounts for ~50% of all nail diseases. The treatment of onychomycosis includes systemic and topical approaches, which depend on patient compliance, drug penetration and delivery to the nail bed, antifungal efficacy, and tolerance. Efinaconazole is a novel triazole antifungal agent that is active against many pathogenic fungi, and is used for treating onychomycosis. Objective: To confirm the efficacy and safety of 10% efinaconazole solution for treating onychomycosis. Methods: This study was conducted as a 52-week, multicenter, open, single-group, phase 4 clinical trial. A 10% efinaconazole solution was applied on the toenails of each subject before bedtime, once a day for 48 weeks. The subjects visited the test facility every four weeks for the evaluation of the efficacy and safety of the treatment. Results: At 52 weeks of applying 10% efinaconazole solution, the rates of complete cure, mycological cure, complete or almost complete cure, and clinical effectiveness were 16.7%, 95.8%, 38.54%, and 52.1%, respectively. The clinical effects of efinaconazole were seen in more than half of the subjects. No severe adverse reactions related to efinaconazole were observed. Background: Onychomycosis is a common nail fungal infection that affects the nail bed, plate, and matrix. It accounts for ~50% of all nail diseases. The treatment of onychomycosis includes systemic and topical approaches, which depend on patient compliance, drug penetration and delivery to the nail bed, antifungal efficacy, and tolerance. Efinaconazole is a novel triazole antifungal agent that is active against many pathogenic fungi, and is used for treating onychomycosis. Objective: To confirm the efficacy and safety of 10% efinaconazole solution for treating onychomycosis. Methods: This study was conducted as a 52-week, multicenter, open, single-group, phase 4 clinical trial. A 10% efinaconazole solution was applied on the toenails of each subject before bedtime, once a day for 48 weeks. The subjects visited the test facility every four weeks for the evaluation of the efficacy and safety of the treatment. Results: At 52 weeks of applying 10% efinaconazole solution, the rates of complete cure, mycological cure, complete or almost complete cure, and clinical effectiveness were 16.7%, 95.8%, 38.54%, and 52.1%, respectively. The clinical effects of efinaconazole were seen in more than half of the subjects. No severe adverse reactions related to efinaconazole were observed.
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참고문헌 (12)
참고문헌 신청
Beuscher TL / 2019 / Onychomycosis: Diagnosis, treatment, and prevention / J Wound Ostomy Continence Nurs 46:333~335
Piraccini BM / 2010 / Long-term follow-up of toenail onychomycosis caused by dermatophytes after successful treatment with systemic antifungal agents / J Am Acad Dermatol 62:411~414
Cuchi-Burgos E / 2020 / Commercial real time PCR implementation for rapid diagnosis of onychomycosis: A new workflow in a clinical laboratory / Enferm Infecc Microbiol Clin
Gupta AK / 2020 / Monotherapy for toenail onychomycosis : a systematic review and network meta-analysis / Br J Dermatol 182:287~299
Bhatt V / 2015 / Efinaconazole topical solution, 10%:formulation development program of a new topical treatment of toenail onychomycosis / J Pharm Sci 104:2177~2182
Piraccini BM / 2010 / Long-term follow-up of toenail onychomycosis caused by dermatophytes after successful treatment with systemic antifungal agents / J Am Acad Dermatol 62:411~414
Cuchi-Burgos E / 2020 / Commercial real time PCR implementation for rapid diagnosis of onychomycosis: A new workflow in a clinical laboratory / Enferm Infecc Microbiol Clin
Gupta AK / 2020 / Monotherapy for toenail onychomycosis : a systematic review and network meta-analysis / Br J Dermatol 182:287~299
Bhatt V / 2015 / Efinaconazole topical solution, 10%:formulation development program of a new topical treatment of toenail onychomycosis / J Pharm Sci 104:2177~2182
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