지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Bioactive glasses are traditionally associated with bonding to bone through a hydroxycarbonate apatite (HCA) surface layer but the release of active ions is more important for bone regeneration. They are now being used to deliver ions for soft tissue applications, particularly wound healing. Cobalt is known to simulate hypoxia and provoke angiogenesis. The aim here was to develop new bioactive glass compositions designed to be scaffold materials to locally deliver pro-angiogenic cobalt ions, at a controlled rate, without forming an HCA layer, for wound healing applications. Methods: New melt-derived bioactive glass compositions were designed that had the same network connectivity (mean number of bridging covalent bonds between silica tetrahedra), and therefore similar biodegradation rate, as the original 45S5 Bioglass. The amount of magnesium and cobalt in the glass was varied, with the aim of reducing or removing calcium and phosphate from the compositions. Electrospun poly(ε-caprolactone)/bioactive glass composites were also produced. Glasses were tested for ion release in dissolution studies and their influence on Hypoxia-Inducible Factor 1-alpha (HIF-1α) and expression of Vascular Endothelial Growth Factor (VEGF) from fibroblast cells was investigated. Results: Dissolution tests showed the silica rich layer differed depending on the amount of MgO in the glass, which influenced the delivery of cobalt. The electrospun composites delivered a more sustained ion release relative to glass particles alone. Exposing fibroblasts to conditioned media from these composites did not cause a detrimental effect on metabolic activity but glasses containing cobalt did stabilise HIF-1α and provoked a significantly higher expression of VEGF (not seen in Co-free controls). Conclusions: The composite fibres containing new bioactive glass compositions delivered cobalt ions at a sustained rate, which could be mediated by the magnesium content of the glass. The dissolution products stabilised HIF-1α and provoked a significantly higher expression of VEGF, suggesting the composites activated the HIF pathway to stimulate angiogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (99)
참고문헌 신청
Jones JR / 2013 / Review of bioactive glass : from Hench to hybrids / Acta Biomater 9(1):4457~4486
Rahaman MN / 2011 / Bioactive glass in tissue engineering / Acta Biomater 7(6):2355~2373
Hench LL / 2015 / Opening paper 2015-some comments on bioglass : four eras of discovery and development / Biomedical Glasses 1(1):1~11
Jones JR / 2016 / Bioglass and bioactive glasses and their impact on healthcare / Int J Appl Glas Sci 7(4):423~434
Hench LL / 1971 / Bonding mechanisms at the interface of ceramic prosthetic materials / J Biomed Mater Res Symp 2(1):117~141
Rahaman MN / 2011 / Bioactive glass in tissue engineering / Acta Biomater 7(6):2355~2373
Hench LL / 2015 / Opening paper 2015-some comments on bioglass : four eras of discovery and development / Biomedical Glasses 1(1):1~11
Jones JR / 2016 / Bioglass and bioactive glasses and their impact on healthcare / Int J Appl Glas Sci 7(4):423~434
Hench LL / 1971 / Bonding mechanisms at the interface of ceramic prosthetic materials / J Biomed Mater Res Symp 2(1):117~141
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Application of bioactive glasses in various dental fields
생체재료학회지
2022 .09
-
Calcium phosphate cements containing nano-sized bioactive glass as injectable bone substitutes
대한치과재료학회 학술대회
2015 .04
-
Development of folate functionalized bioactive glass nanoparticles for drug-free nanotherapy of inflamed tissues
대한치과재료학회 학술대회
2020 .10
-
Use of smart glasses for ultrasound-guided peripheral venous access: a randomized controlled pilot study
Clinical and Experimental Emergency Medicine
2019 .01
-
Osteoblast behaviours on nanorod hydroxyapatite-grafted glass surfaces
생체재료학회지
2020 .01
-
Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy
Yonsei Medical Journal
2017 .01
-
Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence
Parasites, Hosts and Diseases
2022 .10
-
Mesoporous Bioactive Glass nanoparticle cement for forming bone regeneration
대한치과재료학회 학술대회
2018 .04
-
Clinicopathologic significance of the delta-like ligand 4, vascular endothelial growth factor, and hypoxia-inducible factor-2α in gallbladder cancer
Journal of Pathology and Translational Medicine
2023 .03
-
저산소 조건에 의한 HepG2 세포주의 성장에서 HIF-1α 비의존적 기전의 확인
Journal of Liver Cancer
2016 .01
-
코발트 취급사업장의 공기 중 코발트 노출평가
한국산업보건학회지
2015 .01
-
GLASS Classification: How to Implement into Our Daily Practice
대한외과학회 학술대회 초록집
2021 .11
-
Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?
Vascular Specialist International
2021 .09
-
Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner
Parasites, Hosts and Diseases
2019 .04
-
Current aspects and prospects of glass ionomer cements for clinical dentistry
Journal of Yeungnam Medical Science
2020 .01
-
Development of therapeutic ion doped mesoporous bioactive glass nanoparticle for pulp regeneration
대한치과재료학회 학술대회
2015 .11
-
Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1α
Yonsei Medical Journal
2015 .01
-
Effects of Bioactive Glass on Microhardness of Bleached Enamel Surface
대한치과재료학회지
2018 .03
-
Electrospun wound dressings containing bioactive natural products: physico-chemical characterization and biological assessment
생체재료학회지
2021 .09
-
Investigating the mechanical, physical, and biological characteristics of zinc phosphate dental cement with nano-size copper bioactive glass
대한치과재료학회 학술대회
2022 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0