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논문 기본 정보

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학술저널
저자정보
Vasileios Sakalis (Department of Urology Agios Pavlos General Hospital) Vasileios Sfiggas (Department of Urology Hippokration General Hospital) Ioannis Vouros (Department of Urology Hippokration General Hospital) George Salpiggidis (Department of Urology Hippokration General Hospital) Athanasios Papathanasiou (Department of Urology Hippokration General Hospital) Apostolos Apostolidis (The 2nd Department of Urology Papageorgiou General Hospital Aristotle University of Thessaloniki)
저널정보
대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제25권 제1호
발행연도
2021.1
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69 - 76 (8page)

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Purpose: Several trials have shown that in men with overactive bladder (OAB) and benign prostate enlargement (BPE), the combination of an α-blocker with an anticholinergic is superior to α-blocker monotherapy. The purpose of this study is to explore whether urodynamic detrusor overactivity (DO) affects clinical outcomes in men with BPE and OAB. Methods: This is a post hoc analysis of a prospective, randomized trial, designed to evaluate the changes of morphometric parameters of the prostate following monotherapy or combination therapy in men with BPE-OAB. The initial study recruited men aged ≥50 years, with BPE and predominantly storage lower urinary tract symptoms (LUTS). Patients were randomized to receive tamsulosin monotherapy or a combination of tamsulosin and solifenacin for 26 weeks. All participants completed a 3-day bladder diary and the International Prostate Symptom Score (IPSS), and then underwent pressure-flow and ultrasonographic studies. Data were stratified and analysed based on the urodynamic observation of DO at baseline (DO vs. non-DO). The primary endpoint was the mean change in urgency episodes from baseline. Secondary outcomes were the changes in nocturia, total IPSS, and urodynamic parameters. Results: Sixty-nine men were initially randomized, but only 60 men were included in this analysis. Urgency episodes significantly improved in men with DO who received combination therapy compared to the DO monotherapy subgroup (P=0.04) or to the non-DO combination treatment subgroup (P=0.038). Nocturia also improved in the DO combination treatment subgroup as compared to the non-DO combination subgroup (P=0.037). The 24-hour frequency and total IPSS significantly improved from baseline without significant differences among the subgroups. Conclusions: The present study suggests that baseline DO could be a prognostic factor for a better response to combination therapy over monotherapy in men with BPE and storage LUTS.
#Urinary bladder #Overactive #Benign prostate hyperplasia #Lower urinary tract symptoms #Urgency #Detrusor overactivity

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참고문헌 (35)

참고문헌 신청
Elbadawi A / 1989 / Morphometry of the obstructed detrusor. I. Review of the issues / Neurourol Urodyn 8:163~171 google schola Steers WD / 1996 / Immunity to nerve growth factor prevents afferent plasticity following urinary bladder hypertrophy / J Urol 155:379~385 google schola Irwin DE / 2006 / Population based survey of urinary incontinence, overactive bladde, and other lower urinary tract symptoms in five countries:results of the EPIC study / Eur Urol 50:1306~1315 google schola Haylen BT / 2007 / Is sensory urgency part of the same spectrum of bladder dysfunction as detrusor overactivity / Int Urogynecol J Pelvic floor Dysfunct 18:123~128 google schola Apostolidis A / 2006 / Effect of intravesical Resiniferatoxin (RTX) on lower urinary tract symptoms, urodynamic parameters and quality of life of patients with urodynamic increased bladder sensation / Eur Urol 50:1299~1305 google schola

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