지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 494 - 502 (9page)
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초록· 키워드
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Purpose: The present study compared the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) in Koreanpatients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). Materials and Methods: The medical records of 69 patients with MPA and GPA who received cyclophosphamide and subsequentlyreceived AZA or MMF for remission maintenance therapy were reviewed. All-cause mortality, relapse, end-stage renal disease(ESRD), cerebrovascular accident, and cardiovascular disease were evaluated as poor outcomes. Having a lower BirminghamVasculitis Activity Score (BVAS) was defined as the lowest tertile of BVAS (BVAS ≤11 in this study). Results: In comparative analysis of the occurrence of poor outcomes among patients taking AZA only, MMF only, and MMF afterAZA, patients taking MMF only exhibited a significantly lower cumulative ESRD-free survival rate than patients taking AZA only(p=0.028). In terms of ESRD occurrence between the groups based on BVAS at diagnosis, among patients with MPA and GPA withhigher BVAS at diagnosis, patients taking MMF only exhibited a significantly lower cumulative ESRD-free survival rate than thosetaking AZA only (p=0.047). Among patients with MPA and GPA with the lowest tertile of BVAS at diagnosis, cumulative ESRD-freesurvival rates did not differ. Conclusion: With regard to ESRD occurrence, the efficacy of MMF in remission maintenance therapy was less effective than AZAin patients with MPA and GPA. However, among patients with lower BVAS, there was no difference in the occurrence of poor outcomesbetween patients taking MMF and those taking AZA.
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참고문헌 (16)
참고문헌 신청
Jennette JC / 2013 / 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides / Arthritis Rheum 65:1~11
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Yates M / 2016 / EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis / Ann Rheum Dis 75:1583~1594
Horning K / 2014 / Azathioprine-induced rapid hepatotoxicity / J Pharm Technol 30:18~20
Varma PP / 1996 / Azathioprine induced bone marrow suppression in live related renal allograft recipients / Med J Armed Forces India 52:45~47
Watts R / 2007 / Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies / Ann Rheum Dis 66:222~227
Yates M / 2016 / EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis / Ann Rheum Dis 75:1583~1594
Horning K / 2014 / Azathioprine-induced rapid hepatotoxicity / J Pharm Technol 30:18~20
Varma PP / 1996 / Azathioprine induced bone marrow suppression in live related renal allograft recipients / Med J Armed Forces India 52:45~47
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