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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 455 - 458 (4page)
- DOI
- https://doi.org/10.3904/kjm.2019.94.5.455
이용수
초록· 키워드
오류제보하기
Mycophenolate mofetil (MMF) is an immunosuppressive agent used to treat severe lupus, including lupus nephritis. Common adverse effects of MMF include gastrointestinal and hematological manifestations; however, cardiac toxicity in association with MMF has not been reported. We present a 21-year-old woman with lupus nephritis who developed ventricular tachycardia 2 hours after an overdose of MMF (34 g). Ventricular bigeminy was documented 12 hours after the MMF overdose. Transthoracic echocardiography showed no evidence of structural heart disease. The ventricular arrhythmia was successfully treated with potassium replacement, hydration, and cholestyramine. This case suggests that an overdose of MMF can induce ventricular tachycardia, and electrocardiogram monitoring is critical to identify this rare cardiac complication of MMF.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Korean College of Rheumatology / 2018 / KCR textbook of rheumatology / Panmun Education
Frieling U / 2002 / Mycophenolate mofetil and leflunomide : promising compounds for the treatment of skin diseases / Clin Exp Dermatol 27:562~570
Moore RA / 2006 / Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis / Arthritis Res Ther 8:R182
Filler G / 2014 / Do we need to worry about mycophenolate overdose / Expert Opin Drug Saf 13:521~524
Ceschi A / 2014 / Acute mycophenolate overdose : case series and systematic literature analysis / Expert Opin Drug Saf 13:525~534
Frieling U / 2002 / Mycophenolate mofetil and leflunomide : promising compounds for the treatment of skin diseases / Clin Exp Dermatol 27:562~570
Moore RA / 2006 / Systematic review and meta-analysis of randomised trials and cohort studies of mycophenolate mofetil in lupus nephritis / Arthritis Res Ther 8:R182
Filler G / 2014 / Do we need to worry about mycophenolate overdose / Expert Opin Drug Saf 13:521~524
Ceschi A / 2014 / Acute mycophenolate overdose : case series and systematic literature analysis / Expert Opin Drug Saf 13:525~534
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