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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 211 - 211 (1page)
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Menopause is the natural physiological process caused by less reproductive hormones by ovaries and degrades the quality of life. Hormone replacement therapy was primarily used to reduce menopausal symptoms, but new therapies are needed because they have a risk in long-term use. Probiotics are well known for their beneficial effects on bowel health, obesity and immunity, and they are reported to have useful effects on menopause in recent years. Our previous studies showed that the efficacy of Lactobacillus acidophilus YT1 on menopausal symptoms in ovariectomized (OVX) rats. Treatment of L. acidophilus YT1 (3.7×10<SUP>5</SUP> CFU/mL/head/day) for twelve weeks restored increased pain sensitivity, depression-related behavior, fat mass, and decreased bone mineral density than OVX rats.
To investigate the efficacy of L. acidophilus YT1 in clinical trial, multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40∼60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥20 were performed. Subjects were administered 1×10<SUP>8</SUP> CFU/day L. acidophilus YT1 or placebo, with the primary endpoint being total KMI score, and the effect of secondary endpoints on ... 전체 초록 보기
To investigate the efficacy of L. acidophilus YT1 in clinical trial, multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40∼60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥20 were performed. Subjects were administered 1×10<SUP>8</SUP> CFU/day L. acidophilus YT1 or placebo, with the primary endpoint being total KMI score, and the effect of secondary endpoints on ... 전체 초록 보기
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