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논문 기본 정보

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학술저널
저자정보
강미진 (Humidifier Disinfectant Health Center Asan Medical Center Seoul Korea.) 이소연 (서울아산병원) 박윤미 (Asan Institute for Life Science Asan Medical Center Seoul Korea.) 김봉수 (Department of Life Science Multidisciplinary Genome Institute Hallym University Chuncheon Korea.) 이민정 (Department of Life Science Multidisciplinary Genome Institute Hallym University Chuncheon Korea.) 김정현 (Department of Medicine University of Ulsan Collage of Medicine Seoul Korea.) 정선미 (Asan Institute for Life Science Asan Medical Center University of Ulsan College of Medicine Seoul K) 이승화 (Asan Institute for Life Science Asan Medical Center University of Ulsan College of Medicine Seoul K) 박민지 (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M) 이은상 (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M) 정성수 (Department of Pediatrics Pusan National University Yangsan Hospital Yangsan Korea.) 윤지선 (Department of Pediatrics Mediplex Sejong Hospital Incheon Korea.) 조현주 (Department of Pediatrics International St. Mary's Hospital Catholic Kwandong University College of) 이은 (Department of Pediatrics Chonnam National University Hospital Chonnam National University Medical S) 양송이 (한림대학교) 서동인 (Department of Pediatrics Seoul National University College of Medicine Seoul Korea.) 김경원 (Department of Pediatrics Yonsei University College of Medicine Seoul Korea.) 신연호 (Department of Pediatrics CHA Gangnam Medical Center CHA University College of Medicine Seoul Korea.) 안강모 (삼성서울병원) 홍수종 (울산대학교)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.3
발행연도
2021.1
수록면
404 - 419 (16page)

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Purpose Interleukin (IL)-17 variants and perturbations in the gut microbiota may influence the development of atopic dermatitis (AD). However, unifying principles for variants of host and microbe interaction remains unclear. We sought to investigate whether IL-17 variants and gut microbiota affect the development of AD in infancy. Methods Composition of the gut microbiota was analyzed in fecal samples from 99 normal healthy and 61 AD infants at 6 months of age. The associations between total immunoglobulin E (IgE), the scoring atopic dermatitis (SCORAD), short-chain fatty acids, transcriptome and functional profile of the gut measured in these subjects and Streptococcus were analyzed. IL-6 and IL-8 in the human intestinal epithelial cell line (HIEC-6) were measured after stimulation of IL-17 and Streptococcus mitis. Results In this study, Streptococcus was enriched in infants with AD and was higher in those with the GA + AA of IL-17 (rs2275913) variant. Streptococcus was positively correlated with IgE and SCORAD in infants with AD and GA + AA of IL-17. Butyrate and valerate were negatively correlated with Streptococcus and were decreased in infants with AD and GA + AA. Bacterial genes for oxidative phosphorylation induced by reduced colonization of Clostridium were decreased compared with normal and GG. In transcriptome analysis, lactate dehydrogenase A-like 6B was higher in infants with AD compared with healthy infants. IL-6 and IL-8 were increased in IL-17 and/or S. mitis-stimulated HIEC-6 cells. Conclusions These findings suggest that increased Streptococcus and A allele of IL-17 (rs2275913) may contribute to the pathogenesis of AD via modulation of the immune system in infancy.
#Atopic dermatitis #gastrointestinal microbiome #Streptococcus #IL-17

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참고문헌 (50)

참고문헌 신청
Asher MI / 2006 / Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood : ISAAC Phases One and Three repeat multicountry cross-sectional surveys / Lancet 368:733~743 google schola Lee JY / 2012 / Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis / Int Arch Allergy Immunol 157:363~371 google schola Lee SY / 2014 / Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis: a birth cohort study (COCOA) / PLoS One 9:e96603 google schola Kim H / 2019 / Birth mode, breastfeeding, pet exposure, and antibiotic use : associations with the gut microbiome and sensitization in children / Curr Allergy Asthma Rep 19:22 google schola 김하정 / 2020 / Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids / Allergy, Asthma & Immunology Research 12(1):137~148 dbpia

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