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논문 기본 정보
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IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that allow for interaction with different molecules intracellularly or extracellularly. The longest variant is IL-32γ possessing 234 amino acid residues with all 11 protein domains, while the shortest variant is IL-32α possessing 131 amino acid residues with three of the protein domains. The first domain exists in 6 variants except IL-32δ variant, which has a distinct translation initiation codon due to mRNA splicing. The last eleventh domain is common domain for all seven IL-32 variants. Numerous studies in different fields, such as inflammation, autoimmunity, pathogen infection, and cancer biology, have claimed the specific biological activity of individual IL-32 variant despite the absence of sufficient data. There are 4 additional IL-32 variants without proper transcripts. In this review, the structural characteristics of seven IL-32 transcripts are described based on the specific protein domains.
목차
ABSTRACT
SEVEN IL-32 VARIANTS WITH ELEVEN PROTEIN DOMAINS
IL-32 VARIANTS IN DIFFERENT DISEASES
CONCLUSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Choi JD / 2009 / Identification of the most active interleukin-32 isoform / Immunology 126:535~542
Cho KA / 2010 / Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway / Microb Pathog 49:95~104
Calabrese F / 2008 / IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease / Am J Respir Crit Care Med 178:894~901
Kim SH / 2005 / Interleukin-32: a cytokine and inducer of TNFα / Immunity 22:131~142
Choi J / 2010 / Paradoxical effects of constitutive human IL-32γ in transgenic mice during experimental colitis / Proc Natl Acad Sci U S A 107:21082~21086
Cho KA / 2010 / Orientia tsutsugamushi induced endothelial cell activation via the NOD1-IL-32 pathway / Microb Pathog 49:95~104
Calabrese F / 2008 / IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease / Am J Respir Crit Care Med 178:894~901
Kim SH / 2005 / Interleukin-32: a cytokine and inducer of TNFα / Immunity 22:131~142
Choi J / 2010 / Paradoxical effects of constitutive human IL-32γ in transgenic mice during experimental colitis / Proc Natl Acad Sci U S A 107:21082~21086
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UCI(KEPA) : I410-ECN-0101-2019-517-000786760