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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 743 - 750 (8page)
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초록· 키워드
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Background Preterm birth (PTB) is a major adverse pregnancy outcome and largely contributes to increasing neonatal and maternal mortality. Genetic and environmental factors may play an important role in the development of PTB. Numerous studies have shown that immune genes related to the immune system, such as IL-6, IL-10, and TNFα, are associated with the occurrence of PTB. Objective We examined genetic associations between IL-6 rs1800796, IL-10 rs1800872, and TNFα rs1800630 polymorphisms and PTB in Korean women. Methods In this study, 115 PTB patients and 147 controls were analyzed. The genotyping of three SNPs was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results Our result showed that the rs1800872 polymorphism was significantly associated with the development of PTB in genotype frequency (odds ratio (OR) 1.71, 95% confidence interval (CI) 1.01–2.90, p = 0.046). We also found a significant association in an analysis of combined genotypes (rs1800796 CC, rs1800872 CA, and rs1800630 CA) (OR 7.43, 95% CI 2.06–26.84, p = 0.001). In a correlation analysis, rs1800630 A allele was significantly related with the increased birth weight (g) within PTB patients (p = 0.005). Conclusion Our results imply possible relationships between the rs1800796, rs1800872, and rs1800630 polymorphisms and the development of PTB.
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참고문헌 (51)
참고문헌 신청
Amory JH / 2004 / Adverse outcomes after preterm labor are associated with tumor necrosis factor-a polymorphism-863, but not-308, in mother-infant pairs / Am J Obstet Gynecol 191:1362~1367
Asifa GZ / 2013 / Tumor necrosis factor-alpha gene promoter region polymorphism and the risk of coronary heart disease / Sci World J 2013:203492
Bahadori M / 2014 / IL-6, IL-10 and IL-17 gene polymorphisms in Iranian women with recurrent miscarriage / Iran J Immunol 11:97~104
Behrman RE / 2007 / Preterm birth: causes, consequences, and prevention / National Academies Press :31~52
Cappelietti M / 2015 / Inflammation and preterm birth / J Leukoc Biol 99:67~78
Asifa GZ / 2013 / Tumor necrosis factor-alpha gene promoter region polymorphism and the risk of coronary heart disease / Sci World J 2013:203492
Bahadori M / 2014 / IL-6, IL-10 and IL-17 gene polymorphisms in Iranian women with recurrent miscarriage / Iran J Immunol 11:97~104
Behrman RE / 2007 / Preterm birth: causes, consequences, and prevention / National Academies Press :31~52
Cappelietti M / 2015 / Inflammation and preterm birth / J Leukoc Biol 99:67~78
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