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논문 기본 정보

자료유형
학술저널
저자정보
Jee Hee Yoon (Chonnam National University Hwasun Hospital) 신민호 (전남대학교의과대학 예방의학교실) 김희남 (Preventive Medicine Chonnam National University Medical School Korea) 최원석 (Departments of Internal Medicine Chonnam National University Medical School Korea) 박지용 (Departments of Internal Medicine Chonnam National University Medical School Korea) 홍아람 (서울대학교병원) 김희경 (전남대학교) 강호철 (전남대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.36 No.3
발행연도
2021.1
수록면
599 - 606 (8page)

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Background: Programmed cell death-ligand 1 (PD-L1) has an important role in regulating immune reactions by binding to programmed death 1 (PD-1) on immune cells, which could prevent the exacerbation of autoimmune thyroid disease (AITD). The aim of this study was to evaluate the association of PD-L1 polymorphism with AITD, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Methods: A total of 189 GD patients, 234 HT patients, and 846 healthy age- and sex-matched controls were enrolled in this study. We analyzed PD-L1 single nucleotide polymorphism (SNP) (rs822339) and investigated the associations with clinical disease course and outcome. Results: Genotype frequency at the PD-L1 marker RS822339 in GD (P=0.219) and HT (P=0.764) patients did not differ from that among healthy controls. In patients with GD, the A/G or G/G genotype group demonstrated higher TBII titer (20.6±20.5 vs. 28.0± 25.8, P=0.044) and longer treatment duration (39.0±40.4 months vs. 62.4±65.0 months, P=0.003) compared to the A/A genotype group. Among patients in whom anti-thyroid peroxidase (TPO) antibody was measured after treatment of GD, post-treatment antiTPO positivity was higher in the A/G or G/G genotype group compared to the A/A genotype group (48.1% vs. 69.9%, P=0.045). Among patients with HT, there was no significant difference of anti-TPO antibody positivity (79.4% vs. 68.6%, P=0.121), anti-thyroglobulin antibody positivity (80.9% vs. 84.7%, P=0.661), or development to overt hypothyroidism (68.0% vs. 71.1%, P=0.632) between the A/A genotype group and the A/G or G/G genotype group. Conclusion: The genotype frequency of PD-L1 (rs822339) is not different in patients with AITD compared with healthy controls. The intact PD-1/PD-L1 pathway in GD and HT might be important to maintain chronicity of AITD by protecting immune tolerance. However, the PD-L1 SNP could be associated with difficulty in achieving remission in patients with GD, which may be helpful to predict the possibility of longer treatment. Further studies are required to investigate the complex immune tolerance system in patients with AITD.
#Immune checkpoint inhibitor #Programmed cell death 1 ligand #Polymorphism #single nucleotide #Graves disease #Hashimoto disease

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참고문헌 (40)

참고문헌 신청
McLeod DS / 2012 / The incidence and prevalence of thyroid autoimmunity / Endocrine 42:252~265 google schola Tomer Y / 2009 / The etiology of autoimmune thyroid disease : a story of genes and environment / J Autoimmun 32:231~239 google schola Alvarez-Sierra D / 2019 / Analysis of the PD-1/PD-L1 axis in human autoimmune thyroid disease : insights into pathogenesis and clues to immunotherapy associated thyroid autoimmunity / J Autoimmun 103:102285 google schola Chen L / 2013 / Molecular mechanisms of T cell co-stimulation and co-inhibition / Nat Rev Immunol 13:227~242 google schola Sage PT / 2018 / Dendritic cell PD-L1 limits autoimmunity and follicular T cell differentiation and function / J Immunol 200:2592~2602 google schola

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